Reactome | BRCA1 C64R [nucleoplasm]

BRCA1 C64R [nucleoplasm]

Stable Identifier

R-HSA-9700907

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Synonyms

BRCA1 Cys64Arg

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Literature References

PubMed ID	Title	Journal	Year
24516540	Characterization of an Italian founder mutation in the RING-finger domain of BRCA1 Caleca, L, Putignano, AL, Colombo, M, Congregati, C, Sarkar, M, Magliery, TJ, Ripamonti, CB, Foglia, C, Peissel, B, Zaffaroni, D, Manoukian, S, Tondini, C, Barile, M, Pensotti, V, Bernard, L, Papi, L, Radice, P	PLoS ONE	2014

External Reference Information

External Reference

UniProt:P38398 BRCA1

Gene Names

BRCA1, RNF53

Chain

chain:1-1863

Reference Genes

BioGPS Gene:672 BRCA1

COSMIC (genes):BRCA1 BRCA1

CTD Gene:672 BRCA1

dbSNP Gene:672 BRCA1

ENSEMBL:ENSG00000012048 BRCA1

HGNC:1100 BRCA1

KEGG Gene (Homo sapiens):672 BRCA1

Monarch:672 BRCA1

NCBI Gene:672 BRCA1

OMIM:113705 BRCA1

UCSC:P38398 BRCA1

Reference Transcript

Other Identifiers

0000510746

11735584_x_at

11744317_x_at

11749632_a_at

11750373_a_at

11755416_x_at

16845349

1993_s_at

204531_s_at

211851_x_at

2395433

33724_at

3506844

3758316

3758318

3758319

3758321

3758323

3758324

3758334

3758335

3758337

3758341

3758342

3758344

3758345

3758350

3758351

3758355

3758357

3758358

3758359

3758360

3758361

3758362

3758363

3758364

3758366

3758367

3758368

3758371

3758372

3758374

3758375

604_at

672

69578_at

8015769

A_23_P207400

GE475511

GE59309

GO:0000151

GO:0000228

GO:0000278

GO:0000724

GO:0000729

GO:0000793

GO:0000794

GO:0000800

GO:0000976

GO:0003674

GO:0003677

GO:0003684

GO:0003713

GO:0003723

GO:0004842

GO:0005515

GO:0005575

GO:0005622

GO:0005634

GO:0005654

GO:0005694

GO:0005737

GO:0005815

GO:0005856

GO:0005886

GO:0006259

GO:0006260

GO:0006281

GO:0006301

GO:0006302

GO:0006303

GO:0006310

GO:0006349

GO:0006357

GO:0006359

GO:0006464

GO:0006629

GO:0006631

GO:0006633

GO:0006915

GO:0006950

GO:0006974

GO:0006978

GO:0007010

GO:0007049

GO:0007059

GO:0007098

GO:0007165

GO:0008092

GO:0008150

GO:0008219

GO:0008270

GO:0008274

GO:0008283

GO:0008630

GO:0009048

GO:0009058

GO:0009790

GO:0010212

GO:0010575

GO:0010628

GO:0015631

GO:0016567

GO:0016579

GO:0016604

GO:0016740

GO:0019899

GO:0022607

GO:0031398

GO:0031436

GO:0031625

GO:0032991

GO:0033147

GO:0034641

GO:0035066

GO:0035067

GO:0042127

GO:0042802

GO:0042981

GO:0043009

GO:0043167

GO:0043226

GO:0043627

GO:0044030

GO:0044281

GO:0044818

GO:0045717

GO:0045739

GO:0045766

GO:0045892

GO:0045893

GO:0045944

GO:0046600

GO:0046872

GO:0048646

GO:0048856

GO:0051276

GO:0051571

GO:0051572

GO:0051573

GO:0051574

GO:0051865

GO:0070063

GO:0070317

GO:0070512

GO:0070531

GO:0071158

GO:0071356

GO:0071681

GO:0072425

GO:0085020

GO:1901796

GO:1902042

GO:1990904

GO:2000378

GO:2000617

GO:2000620

ILMN_1738027

ILMN_2311089

L78833_cds1_at

PH_hs_0011459

TC17001553.hg

TC17002645.hg

U64805_s_at

g2218153_3p_a_at

g6552300_3p_a_at

Participant Of

hasMember

BRCA1 mutants (BARD1 binding) [nucleoplasm]

Other forms of this molecule

SUMO2,3-BRCA1 [nucleoplasm]

SUMO1-K109-BRCA1 [nucleoplasm]

BRCA1 C61G [nucleoplasm]

BRCA1 C39Y [nucleoplasm]

BRCA1 H41R [nucleoplasm]

BRCA1 C24R [nucleoplasm]

BRCA1 H41A [nucleoplasm]

BRCA1 M18T [nucleoplasm]

BRCA1 C47G [nucleoplasm]

BRCA1 C64G [nucleoplasm]

BRCA1 C44F [nucleoplasm]

BRCA1 T37R [nucleoplasm]

BRCA1 C27A [nucleoplasm]

BRCA1 H41Q [nucleoplasm]

BRCA1 Q12Tfs*5 [nucleoplasm]

BRCA1 E23Afs*18 [nucleoplasm]

BRCA1 C61Y [nucleoplasm]

BRCA1 C24F [nucleoplasm]

BRCA1 E23Rfs*18 [nucleoplasm]

BRCA1 E23Vfs*17 [nucleoplasm]

p-S988,S1387,S1423,S1524,S1547-BRCA1 [nucleoplasm]

K6PolyUb,p-S988,S1387,S1423,S1524,S1547-BRCA1 [nucleoplasm]

BRCA1 [nucleoplasm]

K6PolyUb-BRCA1 [nucleoplasm]

K6PolyUb,p-S1387,S1423,S1524,S1547-BRCA1 [nucleoplasm]

p-S1387,S1423,S1524,S1547-BRCA1 [nucleoplasm]

Modified Residues

Name

L-cysteine 64 replaced with L-arginine

Coordinate

PsiMod

L-arginine residue [MOD:00011]

A protein modification that effectively converts a source amino acid residue to an L-arginine.

L-cysteine removal [MOD:01635]

A protein modification that effectively removes or replaces an L-cysteine.

Disease

Name	Identifier	Synonyms
breast cancer	1612	malignant tumor of the breast, mammary cancer, malignant neoplasm of breast, mammary tumor, primary breast cancer, breast cancer, Ca breast - NOS, breast tumor
cancer	162	malignant tumor, malignant neoplasm, primary cancer
hereditary breast ovarian cancer syndrome	5683	BRCA1- and BRCA2-associated hereditary breast and ovarian cancer

Cross References

RefSeq

NP_009231.2, NP_009229.2, NP_009230.2, NP_009225.1, NP_009228.2

OpenTargets

ENSG00000012048

ZINC - Substances

BRCA1_HUMAN

GeneCards

P38398

HPA

ENSG00000012048-BRCA1

ZINC target

P38398

Ensembl

ENSP00000312236, ENST00000352993, ENST00000461221, ENST00000461798, ENSG00000012048, ENST00000357654, ENST00000468300, ENST00000471181, ENSP00000418960, ENST00000493795, ENST00000491747, ENSP00000350283, ENSP00000418548, ENSP00000417988, ENSP00000418775, ENSP00000417148, ENSP00000420705

PRO

P38398

ZINC - Predictions - Purchasable

BRCA1_HUMAN

Orphanet

15377

PDB

6G2I, 4U4A, 1OQA, 1T29, 3PXE, 3K0K, 4Y2G, 3K0H, 2ING, 4IGK, 3COJ, 4Y18, 1N5O, 1Y98, 3K15, 3K16, 1T2U, 1T2V, 1T15, 3PXD, 4JLU, 3PXC, 3PXB, 4OFB, 3PXA, 1JM7, 1JNX, 4IFI

Interactors (45)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q9BX63 BRIP1	2	p-S990,Ac-K1249-BRIP1 [nucleoplasm] (R-HSA-5687710) BRIP1 [cytosol] (R-HSA-2564781)	0.976	28
UniProt:Q99728 BARD1	13	BARD1 C71Y [nucleoplasm] (R-HSA-9700808) BARD1 G623E [nucleoplasm] (R-HSA-9699135) BARD1 C53W [nucleoplasm] (R-HSA-9700807) BARD1 G623W [nucleoplasm] (R-HSA-9699148) BARD1 W34R [nucleoplasm] (R-HSA-9699166) p-T714,T734-BARD1 [nucleoplasm] (R-HSA-5659846) K6PolyUb,p-T714,T734-BARD1 [nucleoplasm] (R-HSA-9707286) K6PolyUb-BARD1 [nucleoplasm] (R-HSA-9701024) BARD1 [nucleoplasm] (R-HSA-5659775) BARD1 C83G [nucleoplasm] (R-HSA-9699139) BARD1 C50G [nucleoplasm] (R-HSA-9699137) BARD1 L44R [nucleoplasm] (R-HSA-9699126) BARD1 H68Y [nucleoplasm] (R-HSA-9699151)	0.951	17
UniProt:Q86YC2 PALB2	1	PALB2 [nucleoplasm] (R-HSA-419548)	0.909	27
UniProt:Q99708 RBBP8	4	p-S327,T847,T859-RBBP8 [nucleoplasm] (R-HSA-5684138) Ac-K432,K526,K604-RBBP8 [nucleoplasm] (R-HSA-5685955) p-S327,T847-RBBP8 [nucleoplasm] (R-HSA-5684083) RBBP8 [nucleoplasm] (R-HSA-912399)	0.908	12
UniProt:Q6UWZ7 ABRAXAS1	1	p-S406-FAM175A [nucleoplasm] (R-HSA-5682575)	0.819	15
UniProt:P03372 ESR1	8	SUMO1-5K-ESR1 [nucleoplasm] (R-HSA-4090302) p-S118-ESR1 [nucleoplasm] (R-HSA-9024210) Me260-ESR1 [cytosol] (R-HSA-9632177) PalmS-ESR1 [cytosol] (R-HSA-9020974) PalmS-ESR1 [plasma membrane] (R-HSA-9021057) Me260-PalmS-ESR1 [plasma membrane] (R-HSA-9637788) ESR1 [nucleoplasm] (R-HSA-446168) ESR1 [cytosol] (R-HSA-9020968)	0.811	16
UniProt:O15360 FANCA	1	FANCA [nucleoplasm] (R-HSA-419541)	0.753	5
UniProt:P51587 BRCA2	2	BRCA2 [nucleoplasm] (R-HSA-50951) p-T3387-BRCA2 [nucleoplasm] (R-HSA-5685241)	0.737	8
UniProt:Q06609 RAD51	2	p-T309-RAD51 [nucleoplasm] (R-HSA-5685231) RAD51 [nucleoplasm] (R-HSA-62637)	0.731	6
UniProt:Q96RL1 UIMC1	1	UIMC1 [nucleoplasm] (R-HSA-5682574)	0.722	10
UniProt:Q14192 FHL2	1	FHL2 [nucleoplasm] (R-HSA-561161)	0.715	6
UniProt:P16104 H2AX	7	Me2sR4-H2AFX [nucleoplasm] (R-HSA-5218317) H2AFX [extracellular region] (R-HSA-977583) K63PolyUb-K14,K16,p-S140-H2AFX [nucleoplasm] (R-HSA-5682847) p-S140-H2AFX [nucleoplasm] (R-HSA-75170) p-S140,Y143-H2AFX [nucleoplasm] (R-HSA-5683953) p-Y143-H2AFX [nucleoplasm] (R-HSA-5683942) H2AFX [nucleoplasm] (R-HSA-56151)	0.714	4
UniProt:Q12888 TP53BP1	3	TP53BP1 [nucleoplasm] (R-HSA-61175) SUMO1-K-TP53BP1 [nucleoplasm] (R-HSA-2997591) p-S25,S1778-TP53BP1 [nucleoplasm] (R-HSA-5683418)	0.714	5
UniProt:P27694 RPA1	2	RPA1 [nucleoplasm] (R-HSA-68461) SUMO2,3-K449,K577-RPA1 [nucleoplasm] (R-HSA-4551644)	0.669	3
UniProt:Q14676 MDC1	6	SUMO2,3-K1840-MDC1 [nucleoplasm] (R-HSA-4570473) SUMO1-K1840-MDC1 [nucleoplasm] (R-HSA-4570546) K48PolyUb,SUMO2-K1840,p-5T-MDC1 [nucleoplasm] (R-HSA-5684074) SUMO2-K1840,p-5T-MDC1 [nucleoplasm] (R-HSA-5684061) MDC1 [nucleoplasm] (R-HSA-75231) p-5T-MDC1 [nucleoplasm] (R-HSA-75236)	0.648	4
UniProt:P78347 GTF2I			0.61	5
UniProt:Q8WX92 NELFB	3	NELFB [cytosol] (R-HSA-9603526) NELFB [mitochondrial outer membrane] (R-HSA-9603553) NELFB [nucleoplasm] (R-HSA-112427)	0.602	5
UniProt:Q6PJG6 BRAT1			0.602	6
UniProt:Q9BXW9 FANCD2	3	p-T691,S717-FANCD2 [nucleoplasm] (R-HSA-6788481) FANCD2 [nucleoplasm] (R-HSA-419522) MonoUb-K561,p-T691,S717-FANCD2 [nucleoplasm] (R-HSA-6785318)	0.602	3
UniProt:P63165 SUMO1	155	TOPORS-G97-SUMO1 [nucleoplasm] (R-HSA-4551623) K14-UBE2I-G97-SUMO1 [nucleoplasm] (R-HSA-4085334) PIAS4-G97-SUMO1 [nucleoplasm] (R-HSA-3968375) K2592-RANBP2-G97-SUMO1 [nuclear envelope] (R-HSA-4551627) K2723-RANBP2-G97-SUMO1 [nuclear envelope] (R-HSA-4551737) K2650-RANBP2-G97-SUMO1 [nuclear envelope] (R-HSA-4551591) K196-VHL-G97-SUMO1 [nucleoplasm] (R-HSA-4551630) K171-VHL-G97-SUMO1 [nucleoplasm] (R-HSA-4551632) K159-VHL-G97-SUMO1 [nucleoplasm] (R-HSA-4551713) MDM-G97-SUMO1 [nucleoplasm] (R-HSA-3730829) K575-TRIM28-G97-SUMO1 [nucleoplasm] (R-HSA-4090305) K804-TRIM28-G97-SUMO1 [nucleoplasm] (R-HSA-3782561) K750-TRIM28-G97-SUMO1 [nucleoplasm] (R-HSA-4090298) K676-TRIM28-G97-SUMO1 [nucleoplasm] (R-HSA-4090396) K554-TRIM28-G97-SUMO1 [nucleoplasm] (R-HSA-3782555) K779-TRIM28-G97-SUMO1 [nucleoplasm] (R-HSA-3782585) ING2-G97-SUMO1 [nucleoplasm] (R-HSA-4086096) K788-Ncoa2-G97-SUMO1 [nucleoplasm] (R-HSA-4085297) K731-Ncoa2-G97-SUMO1 [nucleoplasm] (R-HSA-4085312) K239-Ncoa2-G97-SUMO1 [nucleoplasm] (R-HSA-4085320) K239-NCOA2-G97-SUMO1 [nucleoplasm] (R-HSA-4085299) K731-NCOA2-G97-SUMO1 [nucleoplasm] (R-HSA-4085290) K788-NCOA2-G97-SUMO1 [nucleoplasm] (R-HSA-4085308) NPM1-G97-SUMO1 [nucleoplasm] (R-HSA-4086019) NCOR2-G97-SUMO1 [nucleoplasm] (R-HSA-3927883) DDX17-G97-SUMO1 [nucleoplasm] (R-HSA-3900210) PARK7-G97-SUMO1 [nucleoplasm] (R-HSA-4085344) K1033-CREBBP-G97-SUMO1 [nucleoplasm] (R-HSA-3927910) K1056-CREBBP-G97-SUMO1 [nucleoplasm] (R-HSA-3927954) K998-CREBBP-G97-SUMO1 [nucleoplasm] (R-HSA-3927822) K1154-NRIP1-G97-SUMO1 [nucleoplasm] (R-HSA-4086067) K756-NRIP1-G97-SUMO1 [nucleoplasm] (R-HSA-4086034) DDX5-G97-SUMO1 [nucleoplasm] (R-HSA-3900212) CASP8AP2-G97-SUMO1 [nucleoplasm] (R-HSA-3927863) K1024-EP300-G97-SUMO1 [nucleoplasm] (R-HSA-3899298) K1020-EP300-G97-SUMO1 [nucleoplasm] (R-HSA-3899290) CTBP1-G97-SUMO1 [nucleoplasm] (R-HSA-3730764) K231-SAFB-G97-SUMO1 [nucleoplasm] (R-HSA-4085364) K294-SAFB-G97-SUMO1 [nucleoplasm] (R-HSA-4085341) K624-MKL1-G97-SUMO1 [nucleoplasm] (R-HSA-3900128) K576-MKL1-G97-SUMO1 [nucleoplasm] (R-HSA-3900225) K499-MKL1-G97-SUMO1 [nucleoplasm] (R-HSA-3900219) K631-DAXX-G97-SUMO1 [nucleoplasm] (R-HSA-4086044) K630-DAXX-G97-SUMO1 [nucleoplasm] (R-HSA-4086012) SIN3A-G97-SUMO1 [nucleoplasm] (R-HSA-4086058) PPARGC1A-G97-SUMO1 [nucleoplasm] (R-HSA-3903014) HIPK2-G97-SUMO1 [nucleoplasm] (R-HSA-4090362) K774-NCOA1-G97-SUMO1 [nucleoplasm] (R-HSA-4085292) K732-NCOA1-G97-SUMO1 [nucleoplasm] (R-HSA-4085278) K538-MBD1-G97-SUMO1 [nucleoplasm] (R-HSA-4090416) K499-MBD1-G97-SUMO1 [nucleoplasm] (R-HSA-4090332) ZNF131-G97-SUMO1 [nucleoplasm] (R-HSA-3730875) K90-NFKB2-G97-SUMO1 [cytosol] (R-HSA-4755511) K689-NFKB2-G97-SUMO1 [cytosol] (R-HSA-4755446) K863-NFKB2-G97-SUMO1 [cytosol] (R-HSA-4755412) K298-NFKB2-G97-SUMO1 [cytosol] (R-HSA-4755505) p-S172-IKBKE-G97-SUMO1 [nucleoplasm] (R-HSA-4755408) K309-IKBKG-G97-SUMO1 [nucleoplasm] (R-HSA-4755404) K277-IKBKG-G97-SUMO1 [nucleoplasm] (R-HSA-4755531) NFKBIA-G97-SUMO1 [nucleoplasm] (R-HSA-4656987) AURKA-G97-SUMO1 [cytosol] (R-HSA-4655413) TOP2B-G97-SUMO1 [nucleoplasm] (R-HSA-4641311) TOP1-G97-SUMO1 [nucleoplasm] (R-HSA-4641306) TOP2A-G97-SUMO1 [nucleoplasm] (R-HSA-4641341) K254-PCNA-G97-SUMO1 [nucleoplasm] (R-HSA-4615853) K-PCNA-G97-SUMO1 [nucleoplasm] (R-HSA-4615836) K164-PCNA-G97-SUMO1 [nucleoplasm] (R-HSA-4615951) MDC1-G97-SUMO1 [nucleoplasm] (R-HSA-4570527) STAG2-G97-SUMO1 [nucleoplasm] (R-HSA-3826645) RAD21-G97-SUMO1 [nucleoplasm] (R-HSA-3826574) K411-RAD52-G97-SUMO1 [nucleoplasm] (R-HSA-4568857) K412-RAD52-G97-SUMO1 [nucleoplasm] (R-HSA-4568850) K414-RAD52-G97-SUMO1 [nucleoplasm] (R-HSA-4568900) XRCC4-G97-SUMO1 [nucleoplasm] (R-HSA-4568869) K160-PML-G97-SUMO1 [nucleoplasm] (R-HSA-3730884) K490-PML-G97-SUMO1 [nucleoplasm] (R-HSA-3730833) K65-PML-G97-SUMO1 [nucleoplasm] (R-HSA-3730879) K203-PARP1-G97-SUMO1 [nucleoplasm] (R-HSA-4551625) K486-PARP1-G97-SUMO1 [nucleoplasm] (R-HSA-4551748) K496-WRN-G97-SUMO1 [nucleoplasm] (R-HSA-4568906) K898-WRN-G97-SUMO1 [nucleoplasm] (R-HSA-4568893) K356-WRN-G97-SUMO1 [nucleoplasm] (R-HSA-4568845) RNF168-SUMO1 [nucleoplasm] (R-HSA-4551631) XPC-G97-SUMO1 [nucleoplasm] (R-HSA-4570452) TDG-G97-SUMO1 [nucleoplasm] (R-HSA-4551682) SP100-G97-SUMO1 [nucleoplasm] (R-HSA-3730794) BRCA1-G97-SUMO1 [nucleoplasm] (R-HSA-3730735) RXRA-G97-SUMO1 [nucleoplasm] (R-HSA-4341090) NR5A2-G97-SUMO1 [nucleoplasm] (R-HSA-4755424) K386-AR-G97-SUMO1 [nucleoplasm] (R-HSA-4090321) K520-AR-G97-SUMO1 [nucleoplasm] (R-HSA-4090352) K293-NR3C1-G97-SUMO1 [nucleoplasm] (R-HSA-4341110) K277-NR3C1-G97-SUMO1 [nucleoplasm] (R-HSA-4341057) K389-THRA-G97-SUMO1 [nucleoplasm] (R-HSA-4719415) K283-THRA-G97-SUMO1 [nucleoplasm] (R-HSA-4719434) K399-NR3C2-G97-SUMO1 [nucleoplasm] (R-HSA-4341020) K428-NR3C2-G97-SUMO1 [nucleoplasm] (R-HSA-4341035) K494-NR3C2-G97-SUMO1 [nucleoplasm] (R-HSA-4341093) K89-NR3C2-G97-SUMO1 [nucleoplasm] (R-HSA-4341058) K119-NR5A1-G97-SUMO1 [nucleoplasm] (R-HSA-4546379) K194-NR5A1-G97-SUMO1 [nucleoplasm] (R-HSA-4546380) NR2C1-G97-SUMO1 [nucleoplasm] (R-HSA-4717492) K303-ESR1-G97-SUMO1 [nucleoplasm] (R-HSA-4090373) K266-ESR1-G97-SUMO1 [nucleoplasm] (R-HSA-4090359) K302-ESR1-G97-SUMO1 [nucleoplasm] (R-HSA-4090363) K299-ESR1-G97-SUMO1 [nucleoplasm] (R-HSA-4090349) K268-ESR1-G97-SUMO1 [nucleoplasm] (R-HSA-4090414) K531-PGR-G97-SUMO1 [nucleoplasm] (R-HSA-4341021) K7-PGR-G97-SUMO1 [nucleoplasm] (R-HSA-4341052) K388-PGR-G97-SUMO1 [nucleoplasm] (R-HSA-4341056) K132-NR1H4-G97-SUMO1 [nucleoplasm] (R-HSA-9610527) NR1H4-G97-SUMO1 [nucleoplasm] (R-HSA-4755434) PPARG-G97-SUMO1 [nucleoplasm] (R-HSA-4717445) K395-PPARG-G97-SUMO1 [nucleoplasm] (R-HSA-4717446) PPARA-G97-SUMO1 [nucleoplasm] (R-HSA-4341069) K443-THRB-G97-SUMO1 [nucleoplasm] (R-HSA-4719431) K146-THRB-G97-SUMO1 [nucleoplasm] (R-HSA-4719410) K50-THRB-G97-SUMO1 [nucleoplasm] (R-HSA-4719401) RORA-G97-SUMO1 [nucleoplasm] (R-HSA-4719426) HIC1-G97-SUMO1 [nucleoplasm] (R-HSA-4570544) TP53BP1-G97-SUMO1 [nucleoplasm] (R-HSA-3730731) SP3-G97-SUMO1 [nucleoplasm] (R-HSA-3730646) K423-MITF-G97-SUMO1 [nucleoplasm] (R-HSA-3730755) K289-MITF-G97-SUMO1 [nucleoplasm] (R-HSA-3730738) K25-FOXL2-G97-SUMO1 [nucleoplasm] (R-HSA-3968400) K150-FOXL2-G97-SUMO1 [nucleoplasm] (R-HSA-3968382) K114-FOXL2-G97-SUMO1 [nucleoplasm] (R-HSA-3968396) HNRNPC-G97-SUMO1 [nucleoplasm] (R-HSA-4570515) K497-NOP58-G97-SUMO1 [nucleoplasm] (R-HSA-4570504) K467-NOP58-G97-SUMO1 [nucleoplasm] (R-HSA-4570462) DNMT3B-G97-SUMO1 [nucleoplasm] (R-HSA-4655444) DNMT3A-G97-SUMO1 [nucleoplasm] (R-HSA-4655383) DNMT1-G97-SUMO1 [nucleoplasm] (R-HSA-4655358) K84-CBX5-G97-SUMO1 [nucleoplasm] (R-HSA-4615838) K-CBX5-G97-SUMO1 [nucleoplasm] (R-HSA-4615955) K476-HDAC1-G97-SUMO1 [nucleoplasm] (R-HSA-4615867) K444-HDAC1-G97-SUMO1 [nucleoplasm] (R-HSA-4616028) CBX4-G97-SUMO1 [nucleoplasm] (R-HSA-4551756) HDAC2-G97-SUMO1 [nucleoplasm] (R-HSA-4616032) SUZ12-G97-SUMO1 [nucleoplasm] (R-HSA-4615961) SATB1-G97-SUMO1 [nucleoplasm] (R-HSA-4615877) HDAC4-G97-SUMO1 [nucleoplasm] (R-HSA-4615956) K1971-CHD3-G97-SUMO1 [nucleoplasm] (R-HSA-8956370) HIST1H4-G97-SUMO1 [nucleoplasm] (R-HSA-4570549) BMI1-G97-SUMO1 [nucleoplasm] (R-HSA-4551654) TFAP2B-G97-SUMO1 [nucleoplasm] (R-HSA-3730839) TFAP2C-G97-SUMO1 [nucleoplasm] (R-HSA-3730823) TFAP2A-1-G97-SUMO1 [nucleoplasm] (R-HSA-3730825) UBE2I-G97-SUMO1 [cytosol] (R-HSA-4656941) RANGAP1-G97-SUMO1 [nucleoplasm] (R-HSA-3730796) SUMO1(2-101) [nucleoplasm] (R-HSA-2990831) SUMO1 [nucleoplasm] (R-HSA-877304) UBA2-G97-SUMO1 [nucleoplasm] (R-HSA-3730616) UBE2I-G97-SUMO1 [nucleoplasm] (R-HSA-3730622) HERC2-SUMO1 [nucleoplasm] (R-HSA-4551761)	0.602	3
UniProt:Q61188 Ezh2	1	Ezh2 [nucleoplasm] (R-MMU-5617899)	0.591	5
UniProt:P61956 SUMO2	5	UBA2-G93-SUMO2 [nucleoplasm] (R-HSA-3730618) SUMO2(1-95) [nucleoplasm] (R-HSA-2990837) SUMO2 [nucleoplasm] (R-HSA-2984281) UBE2I-G93-SUMO2 [nucleoplasm] (R-HSA-3730625) MDC1-SUMO2 [nucleoplasm] (R-HSA-5684062)	0.589	2
UniProt:Q9GZX5 ZNF350	1	ZNF350 [nucleoplasm] (R-HSA-1247526)	0.581	3
UniProt:P62140 PPP1CB	4	PPP1CB [cytosol] (R-HSA-163405) PPP1CB [nucleoplasm] (R-HSA-62003) PPP1CB P49R [cytosol] (R-HSA-9660547) PPP1CB A56P [cytosol] (R-HSA-9660543)	0.581	3
UniProt:P38398 BRCA1	27	SUMO1-K109-BRCA1 [nucleoplasm] (R-HSA-2997644) SUMO2,3-BRCA1 [nucleoplasm] (R-HSA-2997624) BRCA1 C64R [nucleoplasm] (R-HSA-9700907) BRCA1 C61G [nucleoplasm] (R-HSA-9700890) BRCA1 C39Y [nucleoplasm] (R-HSA-9700938) BRCA1 H41R [nucleoplasm] (R-HSA-9700921) BRCA1 C24R [nucleoplasm] (R-HSA-9663198) BRCA1 H41A [nucleoplasm] (R-HSA-9700927) BRCA1 M18T [nucleoplasm] (R-HSA-9700911) BRCA1 C47G [nucleoplasm] (R-HSA-9700941) BRCA1 C64G [nucleoplasm] (R-HSA-9700899) BRCA1 C44F [nucleoplasm] (R-HSA-9700944) BRCA1 T37R [nucleoplasm] (R-HSA-9700934) BRCA1 C27A [nucleoplasm] (R-HSA-9700916) BRCA1 H41Q [nucleoplasm] (R-HSA-9700923) BRCA1 Q12Tfs5 [nucleoplasm] (R-HSA-9700953) BRCA1 E23Afs18 [nucleoplasm] (R-HSA-9700959) BRCA1 C61Y [nucleoplasm] (R-HSA-9700894) BRCA1 C24F [nucleoplasm] (R-HSA-9663206) BRCA1 E23Rfs18 [nucleoplasm] (R-HSA-9700960) BRCA1 E23Vfs17 [nucleoplasm] (R-HSA-9700967) p-S988,S1387,S1423,S1524,S1547-BRCA1 [nucleoplasm] (R-HSA-5683800) K6PolyUb,p-S988,S1387,S1423,S1524,S1547-BRCA1 [nucleoplasm] (R-HSA-9707298) BRCA1 [nucleoplasm] (R-HSA-50949) K6PolyUb-BRCA1 [nucleoplasm] (R-HSA-9701022) K6PolyUb,p-S1387,S1423,S1524,S1547-BRCA1 [nucleoplasm] (R-HSA-9707290) p-S1387,S1423,S1524,S1547-BRCA1 [nucleoplasm] (R-HSA-75234)	0.564	2
UniProt:Q16666 IFI16	1	IFI16 [cytosol] (R-HSA-1834934)	0.556	9
UniProt:P03126 VE6			0.544	7
UniProt:P03129 VE7			0.544	5
UniProt:P04637 TP53	27	TP53 [cytosol] (R-HSA-8869337) Unfolded TP53 [cytosol] (R-HSA-6813797) PolyUb-TP53 [nucleoplasm] (R-HSA-6782509) SUMO2,3-K386-TP53 [nucleoplasm] (R-HSA-2997661) Me2K-370,382-TP53 [nucleoplasm] (R-HSA-3222242) p-S15,S33,S46-TP53 [nucleoplasm] (R-HSA-6805268) p-S15,S392-TP53 [nucleoplasm] (R-HSA-3222015) p-T55-TP53 [nucleoplasm] (R-HSA-6805400) p-S15,S20,S392-TP53 [nucleoplasm] (R-HSA-6805053) p-S15,S20,S269,T284-TP53 [nucleoplasm] (R-HSA-6805133) p-S315-TP53 [nucleoplasm] (R-HSA-6805106) Ac-K120,p-S15,S20-TP53 [nucleoplasm] (R-HSA-6805656) Ac-K120,K382,p-S15,S20-TP53 [nucleoplasm] (R-HSA-6805631) Ac-K382,p-S15,S20-TP53 [nucleoplasm] (R-HSA-5628868) Me2-K373-TP53 [nucleoplasm] (R-HSA-6805759) MeK-370,p-S15,S20-TP53 [nucleoplasm] (R-HSA-3222226) p-S15,S20,Me-R333,Me2-R335,R337-TP53 [nucleoplasm] (R-HSA-6804378) Me-K382,p-S15,S20-TP53 [nucleoplasm] (R-HSA-3222124) Me1-K372,p-S15,S20-TP53 [nucleoplasm] (R-HSA-6805719) p-S15,S20,S46-TP53 [nucleoplasm] (R-HSA-6798369) p-S37-TP53 [nucleoplasm] (R-HSA-3239022) PolyUb,p-S15,S20-TP53 [nucleoplasm] (R-HSA-6804446) PolyUb-TP53 [nucleoplasm] (R-HSA-6793679) PolyUb-TP53 [cytosol] (R-HSA-6793681) p-S15,S20-TP53 [nucleoplasm] (R-HSA-69683) p-S15-TP53 [nucleoplasm] (R-HSA-69507) TP53 [nucleoplasm] (R-HSA-69488)	0.544	2
UniProt:Q92560 BAP1	1	BAP1 [nucleoplasm] (R-HSA-5689665)	0.543	3
UniProt:P40692 MLH1	3	MLH1 H329P [nucleoplasm] (R-HSA-5444512) MLH1 S252* [nucleoplasm] (R-HSA-5444526) MLH1 [nucleoplasm] (R-HSA-912495)	0.527	2
UniProt:P46736 BRCC3	2	BRCC3 [nucleoplasm] (R-HSA-5682577) BRCC3 [cytosol] (R-HSA-5691415)	0.527	2
UniProt:Q9ULW0 TPX2	2	TPX2 [cytosol] (R-HSA-8853407) TPX2 [nucleoplasm] (R-HSA-2564700)	0.527	4
UniProt:Q13085 ACACA	2	ACACA [cytosol] (R-HSA-1660609) Btn-ACACA [cytosol] (R-HSA-2976730)	0.524	2
UniProt:P36873 PPP1CC	1	PPP1CC [cytosol] (R-HSA-163443)	0.524	2
UniProt:Q6NZY4 ZCHC8			0.524	2
UniProt:P62136 PPP1CA	1	PPP1CA [cytosol] (R-HSA-163525)	0.524	2
UniProt:P11388 TOP2A	3	SUMO2,3-TOP2A [nucleoplasm] (R-HSA-4641298) TOP2A [nucleoplasm] (R-HSA-1362276) SUMO1-K-TOP2A [nucleoplasm] (R-HSA-4641367)	0.524	3
UniProt:P10809 HSPD1	6	HSPD1 [mitochondrial inner membrane] (R-HSA-1299455) HSPD1 [mitochondrial matrix] (R-HSA-1299448) HSPD1(1-573) [cytosol] (R-HSA-1267989) HSPD1(1-573) [mitochondrial inner membrane] (R-HSA-1299442) HSPD1(1-26) [mitochondrial matrix] (R-HSA-8986171) HSPD1(1-573) [mitochondrial intermembrane space] (R-HSA-1267963)	0.508	2
UniProt:P52292 KPNA2	2	KPNA2 [nucleoplasm] (R-HSA-206045) KPNA2 [cytosol] (R-HSA-205976)	0.508	3
UniProt:Q7Z569 BRAP	2	BRAP [cytosol] (R-HSA-5672938) ub-BRAP [cytosol] (R-HSA-5674001)	0.508	3
UniProt:O75330 HMMR	2	HMMR [cytosol] (R-HSA-8861624) HMMR [plasma membrane] (R-HSA-2160885)	0.499	4
UniProt:O14757 CHEK1	3	CHEK1 [nucleoplasm] (R-HSA-113826) CHEK1 [cytosol] (R-HSA-205285) p-S317,S345-CHEK1 [nucleoplasm] (R-HSA-113838)	0.463	3
UniProt:P24385 CCND1	4	CCND1 [cytosol] (R-HSA-68328) CCND1 [nucleoplasm] (R-HSA-113832) p-T286-CCND1 [cytosol] (R-HSA-75813) p-T286-CCND1 [nucleoplasm] (R-HSA-75811)	0.463	3
UniProt:P10415 BCL2	1	BCL2 [mitochondrial outer membrane] (R-HSA-50757)	0.463	6

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