ASP-3026- resistant ALK mutants don't bind ASP-3026

Stable Identifier
R-HSA-9700646
Type
Reaction [FailedReaction]
Species
Homo sapiens
Compartment
cytosol, plasma membrane
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ASP-3026- resistant ALK mutants don't bind ASP-3026
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The following ALK mutants are resistant to inhibition by ASP-3026:

ALK T1551M: Amin et al 2016
ALK I1171S: Amin et al 2016
ALK I1171T: Katayama et al, 2014
ALK F1174L: Amin et al, 2016 (moderate)
ALKR 1192P: Amin et al, 2016
ALK G1269A: Amin et al, 2016 (moderate)

Literature References
PubMed ID Title Journal Year
25228534 Two novel ALK mutations mediate acquired resistance to the next-generation ALK inhibitor alectinib

Okuno, Y, Iafrate, AJ, Friboulet, L, Koike, S, Shaw, AT, Engelman, JA, Khan, TM, Lockerman, EL, Takeuchi, K, Taiji, M, Fujita, N, Gainor, JF, Katayama, R

Clin Cancer Res 2014
27009859 TKI sensitivity patterns of novel kinase-domain mutations suggest therapeutic opportunities for patients with resistant ALK+ tumors

Gokhale, V, Groysman, MJ, Pongtornpipat, P, Wang, M, Tapia, EO, Rajan, SS, Amin, AD, Schatz, JH, Li, L

Oncotarget 2016
Participants
Input
Participates
as an event of
Normal reaction
(PTN/MDK):ALK dimer binds type I ALK-binding TKIs (Homo sapiens)
Functional status

Loss of function of ASP3026-resistant ALK mutants [plasma membrane]

Normal Entity
Disease Entity
Status
Disease
Name Identifier Synonyms
cancer DOID:162 malignant tumor, malignant neoplasm, primary cancer
Authored
Rothfels, K  (2021-03-22)
Reviewed
Inghirami, G  (2021-05-04)
Created
Rothfels, K  (2020-09-16)
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