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WDCP(1-680)-p-7Y-ALK(1061-1620) fusion [cytosol]
Stable Identifier
R-HSA-9700468
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Synonyms
fullName evidence="13"WD repeat and coiled-coil-containing protein, WDCP_HUMAN
Locations in the PathwayBrowser
Expand all
Disease (Homo sapiens)
Diseases of signal transduction by growth factor receptors and second messengers (Homo sapiens)
Signaling by ALK in cancer (Homo sapiens)
Signaling by ALK fusions and activated point mutants (Homo sapiens)
Autophosphorylation of ALK fusions (Homo sapiens)
p-7Y ALK fusion protein dimers [cytosol] (Homo sapiens)
WDCP(1-680)-p-7Y ALK(1061-1620) fusion dimer [cytosol] (Homo sapiens)
WDCP(1-680)-p-7Y-ALK(1061-1620) fusion [cytosol] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q9H6R7 WDCP
Gene Names
WDCP, C2orf44, PP384
Chain
chain:1-721
Reference Genes
BioGPS Gene:80304 WDCP
COSMIC (genes):WDCP WDCP
CTD Gene:80304 WDCP
dbSNP Gene:80304 WDCP
ENSEMBL:ENSG00000163026 WDCP
ENSEMBL_homo_sapiens_GENE:ENSG00000163026.12 WDCP
HGNC:26157 WDCP
KEGG Gene (Homo sapiens):80304 WDCP
Monarch:80304 WDCP
NCBI Gene:80304 WDCP
OMIM:616234 WDCP
UCSC:Q9H6R7 WDCP
Reference Transcript
RefSeq:NM_025203.2 WDCP
RefSeq:NM_001142319.1 WDCP
Other Identifiers
11715220_s_at
16895165
219120_PM_at
219120_at
2544165
2544166
2544167
2544168
2544169
2544170
2544172
2544173
2544174
2544175
2544176
2544177
2544178
43551_at
63716_at
80304
8050689
A_23_P154022
GE57018
GO:0005515
GO:0019900
GO:0051259
GO:0065003
HMNXSV003052393
ILMN_1730631
PH_hs_0002164
TC02001643.hg
g13376797_3p_at
Participates
as a component of
WDCP(1-680)-p-7Y ALK(1061-1620) fusion dimer [cytosol] (Homo sapiens)
Other forms of this molecule
WDCP(1-680)-ALK(1061-1620) fusion [cytosol]
Modified Residues
Name
Insertion of residues 1061 to 1620 at 681 from UniProt:Q9UM73 ALK
Coordinate
681
Name
O4'-phospho-L-tyrosine at 1278
Coordinate
1278
PsiMod Name
O4'-phospho-L-tyrosine [MOD:00048]
PsiMod Definition
A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.
Name
O4'-phospho-L-tyrosine at 1282
Coordinate
1282
PsiMod Name
O4'-phospho-L-tyrosine [MOD:00048]
PsiMod Definition
A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.
Name
O4'-phospho-L-tyrosine at 1283
Coordinate
1283
PsiMod Name
O4'-phospho-L-tyrosine [MOD:00048]
PsiMod Definition
A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.
Name
O4'-phospho-L-tyrosine at 1096
Coordinate
1096
PsiMod Name
O4'-phospho-L-tyrosine [MOD:00048]
PsiMod Definition
A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.
Name
O4'-phospho-L-tyrosine at 1358
Coordinate
1358
PsiMod Name
O4'-phospho-L-tyrosine [MOD:00048]
PsiMod Definition
A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.
Name
O4'-phospho-L-tyrosine at 1507
Coordinate
1507
PsiMod Name
O4'-phospho-L-tyrosine [MOD:00048]
PsiMod Definition
A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.
Name
O4'-phospho-L-tyrosine at 1604
Coordinate
1604
PsiMod Name
O4'-phospho-L-tyrosine [MOD:00048]
PsiMod Definition
A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.
Disease
Name
Identifier
Synonyms
colon adenocarcinoma
DOID:234
adenocarcinoma of the colon, adenocarcinoma of colon, Colonic adenocarcinoma
Cross References
RefSeq
NP_001135791.1
,
NP_079479.1
COSMIC
COSF1264
OpenTargets
ENSG00000163026
GeneCards
Q9H6R7
HPA
ENSG00000163026-WDCP
Ensembl
ENSG00000163026
,
ENSP00000295148
,
ENSP00000385816
,
ENST00000295148
,
ENST00000406895
PRO
Q9H6R7
Pharos - Targets
Q9H6R7
Interactors (6)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q9Y265 RUVBL1
1
RUVBL1 [nucleoplasm]
(R-HSA-418323)
0.744
6
UniProt:Q9Y230 RUVBL2
1
RUVBL2 [nucleoplasm]
(R-HSA-418321)
0.744
5
UniProt:Q13363 CTBP1
3
monoSUMO1-K428-CTBP1 [nucleoplasm]
(R-HSA-3108200)
polySUMO2,3-K428-CTBP1 [nucleoplasm]
(R-HSA-3108226)
CTBP1 [nucleoplasm]
(R-HSA-212372)
0.725
7
UniProt:P53350 PLK1
4
PLK1 [nucleoplasm]
(R-HSA-156720)
p-T210-PLK1 [cytosol]
(R-HSA-3000318)
p-T210-PLK1 [nucleoplasm]
(R-HSA-3002800)
PLK1 [cytosol]
(R-HSA-164603)
0.527
2
UniProt:O75344 FKBP6
2
FKBP6 [nucleoplasm]
(R-HSA-912512)
FKBP6 [cytosol]
(R-HSA-5601923)
0.527
2
UniProt:Q9UBE8 NLK
3
NLK [cytosol]
(R-HSA-4411330)
p-T298-NLK [cytosol]
(R-HSA-4411398)
p-T298-NLK [nucleoplasm]
(R-HSA-4411376)
0.527
2
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