Autophosphorylation of ALK fusions

Stable Identifier
R-HSA-9700181
Type
Reaction
Species
Homo sapiens
Compartment
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After partner protein-mediated dimerization, ALK fusions are trans-autophosphorylated by the ALK kinase domain, leading to constitutive activation and downstream signaling (reviewed in Roskoski, 2013; Hallberg and Palmer, 2016; Della Corte et al, 2018).

Literature References
PubMed ID Title Journal Year
27573755 The role of the ALK receptor in cancer biology

Hallberg, B, Palmer, RH

Ann Oncol 2016
29455642 Role and targeting of anaplastic lymphoma kinase in cancer

Troiani, T, Viscardi, G, Morgillo, F, Fasano, M, Martinelli, E, Ciardiello, F, Della Corte, CM, Di Liello, R

Mol. Cancer 2018
23201355 Anaplastic lymphoma kinase (ALK): structure, oncogenic activation, and pharmacological inhibition

Roskoski, R

Pharmacol. Res. 2013
Participants
Participates
Catalyst Activity

protein tyrosine kinase activity of ALK fusion protein dimers [cytosol]

Normal reaction
Disease
Name Identifier Synonyms
cancer DOID:162 malignant tumor, malignant neoplasm, primary cancer
Authored
Reviewed
Created
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