Autophosphorylation of ALK fusions

Stable Identifier
R-HSA-9700181
Type
Reaction [transition]
Species
Homo sapiens
Compartment
cytosol
ReviewStatus
5/5
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Autophosphorylation of ALK fusions
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After partner protein-mediated dimerization, ALK fusions are trans-autophosphorylated by the ALK kinase domain, leading to constitutive activation and downstream signaling (reviewed in Roskoski, 2013; Hallberg and Palmer, 2016; Della Corte et al, 2018).

Literature References
PubMed ID Title Journal Year
27573755 The role of the ALK receptor in cancer biology

Hallberg, B, Palmer, RH

Ann Oncol 2016
29455642 Role and targeting of anaplastic lymphoma kinase in cancer

Troiani, T, Viscardi, G, Morgillo, F, Fasano, M, Martinelli, E, Ciardiello, F, Della Corte, CM, Di Liello, R

Mol. Cancer 2018
23201355 Anaplastic lymphoma kinase (ALK): structure, oncogenic activation, and pharmacological inhibition

Roskoski, R

Pharmacol. Res. 2013
Participants
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Output
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as an event of
Catalyst Activity

protein tyrosine kinase activity of ALK fusion protein dimers [cytosol]

Physical Entity
ALK fusion protein dimers [cytosol] (Homo sapiens)
Activity
protein tyrosine kinase activity (GO:0004713)
Normal reaction
ALK autophosphorylation downstream of PTN and MDK (Homo sapiens)
Disease
Name Identifier Synonyms
cancer DOID:162 malignant tumor, malignant neoplasm, primary cancer
Authored
Rothfels, K  (2021-03-22)
Reviewed
Inghirami, G  (2021-05-04)
Created
Rothfels, K  (2020-09-14)
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