Active ALK phosphorylates FRS2

Stable Identifier
R-HSA-9700164
Type
Reaction [transition]
Species
Homo sapiens
Compartment
plasma membrane
ReviewStatus
5/5
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Active ALK phosphorylates FRS2
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FRS2 is phosphorylated downstream of ALK in a manner that depends on ALK kinase activity (Degoutin et al, 2007).

Literature References
PubMed ID Title Journal Year
17274988 ALK activation induces Shc and FRS2 recruitment: Signaling and phenotypic outcomes in PC12 cells differentiation

Vigny, M, Degoutin, J, Gouzi, JY

FEBS Lett. 2007
Participants
Input
Output
Participates
as an event of
Catalyst Activity

protein tyrosine kinase activity of Active ALK:FRS2 [plasma membrane]

Physical Entity
Active ALK:FRS2 [plasma membrane] (Homo sapiens)
Activity
protein tyrosine kinase activity (GO:0004713)
Inferred From
p-7Y ALK dimer phosphorylates Frs2 (Homo sapiens)
Authored
Rothfels, K  (2021-03-30)
Reviewed
Inghirami, G  (2021-05-04)
Created
Rothfels, K  (2020-09-14)
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