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EML4(1-486)-ALK(1058-1620) fusion dimer [cytosol]
Stable Identifier
R-HSA-9700022
Type
Complex
Species
Homo sapiens
Compartment
cytosol
Locations in the PathwayBrowser
Expand all
Disease (Homo sapiens)
Diseases of signal transduction by growth factor receptors and second messengers (Homo sapiens)
Signaling by ALK in cancer (Homo sapiens)
ALK mutants bind TKIs (Homo sapiens)
ALK mutants bind type I TKIs (Homo sapiens)
type I ALK-binding TKIs:type I-sensitive ALK mutants [cytosol] (Homo sapiens)
type I TKI sensitive ALK mutants [plasma membrane] (Homo sapiens)
alectinib sensitve ALK mutants [plasma membrane] (Homo sapiens)
EML4(1-486)-ALK(1058-1620) fusion dimer [cytosol] (Homo sapiens)
ceritinib-sensitive ALK mutants [plasma membrane] (Homo sapiens)
EML4(1-486)-ALK(1058-1620) fusion dimer [cytosol] (Homo sapiens)
crizotinib-sensitive ALK mutants [cytosol] (Homo sapiens)
EML4(1-486)-ALK(1058-1620) fusion dimer [cytosol] (Homo sapiens)
type I TKI sensitive ALK mutants [plasma membrane] (Homo sapiens)
alectinib sensitve ALK mutants [plasma membrane] (Homo sapiens)
EML4(1-486)-ALK(1058-1620) fusion dimer [cytosol] (Homo sapiens)
ceritinib-sensitive ALK mutants [plasma membrane] (Homo sapiens)
EML4(1-486)-ALK(1058-1620) fusion dimer [cytosol] (Homo sapiens)
crizotinib-sensitive ALK mutants [cytosol] (Homo sapiens)
EML4(1-486)-ALK(1058-1620) fusion dimer [cytosol] (Homo sapiens)
Signaling by ALK fusions and activated point mutants (Homo sapiens)
Autophosphorylation of ALK fusions (Homo sapiens)
ALK fusion protein dimers [cytosol] (Homo sapiens)
EML4(1-486)-ALK(1058-1620) fusion dimer [cytosol] (Homo sapiens)
Ligand-independent dimerization of ALK fusions (Homo sapiens)
ALK fusion protein dimers [cytosol] (Homo sapiens)
EML4(1-486)-ALK(1058-1620) fusion dimer [cytosol] (Homo sapiens)
Participants
components
x 2
EML4(1-496)-ALK(1058-1620) fusion [cytosol]
(Homo sapiens)
Participates
as a member of
ALK fusion protein dimers [cytosol] (Homo sapiens)
alectinib sensitve ALK mutants [plasma membrane] (Homo sapiens)
crizotinib-sensitive ALK mutants [cytosol] (Homo sapiens)
ceritinib-sensitive ALK mutants [plasma membrane] (Homo sapiens)
Disease
Name
Identifier
Synonyms
non-small cell lung carcinoma
DOID:3908
Non-small cell lung cancer (disorder), NSCLC, NSCLC
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