semaxanib-sensitive FLT3 mutants [plasma membrane]

Stable Identifier
R-HSA-9699545
Type
Set [DefinedSet]
Species
Homo sapiens
Compartment
plasma membrane
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Literature References
PubMed ID Title Journal Year
12406902 The protein tyrosine kinase inhibitor SU5614 inhibits FLT3 and induces growth arrest and apoptosis in AML-derived cell lines expressing a constitutively activated FLT3

Schnittger, S, Dirschinger, RJ, Schwab, R, Buske, C, Gilliland, DG, Kelly, LM, Faber, F, Spiekermann, K, Bagrintseva, K, Hiddemann, W

Blood 2003
15626738 FLT3-ITD-TKD dual mutants associated with AML confer resistance to FLT3 PTK inhibitors and cytotoxic agents by overexpression of Bcl-x(L)

Ellwart, JW, Reindl, C, Spiekermann, K, Geisenhof, S, Kern, R, Bagrintseva, K, Hiddemann, W, Eichenlaub, S

Blood 2005
12351406 SU5416 and SU5614 inhibit kinase activity of wild-type and mutant FLT3 receptor tyrosine kinase

Heinrich, MC, O'Farrell, AM, Wait, CL, Yee, KW, Griffith, DJ, McGreevey, LS, Smolich, BD, McMahon, G, Cherrington, JM

Blood 2002
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Disease
Name Identifier Synonyms
cancer DOID:162 malignant tumor, malignant neoplasm, primary cancer
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