semaxanib-sensitive FLT3 mutants [plasma membrane]

Stable Identifier
Set [DefinedSet]
Homo sapiens
Locations in the PathwayBrowser
Literature References
PubMed ID Title Journal Year
12406902 The protein tyrosine kinase inhibitor SU5614 inhibits FLT3 and induces growth arrest and apoptosis in AML-derived cell lines expressing a constitutively activated FLT3

Schnittger, S, Dirschinger, RJ, Schwab, R, Buske, C, Gilliland, DG, Kelly, LM, Faber, F, Spiekermann, K, Bagrintseva, K, Hiddemann, W

Blood 2003
15626738 FLT3-ITD-TKD dual mutants associated with AML confer resistance to FLT3 PTK inhibitors and cytotoxic agents by overexpression of Bcl-x(L)

Ellwart, JW, Reindl, C, Spiekermann, K, Geisenhof, S, Kern, R, Bagrintseva, K, Hiddemann, W, Eichenlaub, S

Blood 2005
12351406 SU5416 and SU5614 inhibit kinase activity of wild-type and mutant FLT3 receptor tyrosine kinase

Heinrich, MC, O'Farrell, AM, Wait, CL, Yee, KW, Griffith, DJ, McGreevey, LS, Smolich, BD, McMahon, G, Cherrington, JM

Blood 2002
Name Identifier Synonyms
cancer DOID:162 malignant tumor, malignant neoplasm, primary cancer
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