Assembly of HCMV Procapsid

Stable Identifier
R-HSA-9698932
Type
Reaction [uncertain]
Species
Homo sapiens
Related Species
Human cytomegalovirus
Compartment
Locations in the PathwayBrowser
General
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The procapsid shell is made up of major capsid proteins (MCP)-containing capsomeres, with six copies of MCP per hexon and five copies of MCP per penton. One of the 12 pentons in each capsid is composed entirely of portal protein (PORT), the UL104 protein, a self-assembling homododecamer. The PORT penton provides a channel for viral DNA encapsidation. Triplex (TRI) complex TRI1:TRI2 is added to stabilize hexons and pentons, and small capsid protein (SCP )decorates the outer capsid surface, interacting with MCP at hexon tips.
Before the capsid has aquired the genome, it is designated a B capsid. Three capsid forms accumulate in the nucleus of herpesvirus-infected cells: A capsids that lack both scaffold and packaged viral DNA, B capsids that contain scaffold but lack viral DNA, and C capsids, contains viral DNA in place of scaffold and probably represents nucleocapsids in the process of maturation.

Literature References
PubMed ID Title Journal Year
  Fields Virology

Knipe, DM, Howley, PM

  2013
Participants
Participant Of
hasEvent
Disease
Name Identifier Synonyms
viral infectious disease 934 Viral disease, virus infection, virus infection
Authored
Reviewed
Created
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