C Nucleocapsid Assembly

Stable Identifier
R-HSA-9698931
Type
Reaction [binding]
Species
Homo sapiens
Related Species
Human cytomegalovirus
Compartment
Locations in the PathwayBrowser
General
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An infectious C capsid aquires both tegument and transport protein in the nucleus. A putative capsid vertex capping complex (CVC), composed of UL77 (CVC1) and UL93 (CVC2) proteins, decorates penton tips, and the UL51 and UL52 proteins are added to provide capsid stability. The order of addition of capsid vertex and stabilizing proteins (UL77, UL93, UL51, and UL52) remains to be established. It is not yet resolved whether these proteins are to be considered components of the capsid or tegument. The most capsid-proximal major tegument protein in HCMV is the UL32 protein, pp150, added to nucleocapsids in the nucleus and accompanying maturing particles to the cytoplasm. The pp150 and ppUL96 proteins stabilize nucleocapsids in a common pathway of translocation to cytoplasmic sites of envelopment.

Literature References
PubMed ID Title Journal Year
  Fields Virology

Knipe, DM, Howley, PM

  2013
Participants
Participant Of
hasEvent
Disease
Name Identifier Synonyms
viral infectious disease 934 Viral disease, virus infection, virus infection
Authored
Reviewed
Created
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