Assembly of the HCMV Genome DNA Replication Complex

Stable Identifier
R-HSA-9698927
Type
Reaction [binding]
Species
Homo sapiens
Related Species
Human cytomegalovirus
Compartment
nucleoplasm
ReviewStatus
5/5
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Assembly of the HCMV Genome DNA Replication Complex
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During late stages of Human Cytomegalovirus (HCMV) infection viral DNA replication is established. Viral Proteins, UL36, UL49, UL80, UL100, UL117, UL112-UL113, and TRS1 all play a role in DNA replication. UL76 was found to modulate the expression of the essential protein UL77 possibly as part of a mechanism to modulate UL77 levels required for efficient viral replication. Furthermore UL55 and UL76 were found to inhibit DNA replication suggesting that these viral factors are likely key proteins to fine-tune the replication process.
Literature References
PubMed ID Title Journal Year
  Fields Virology

Knipe, DM, Howley, PM

  2013
Participants
Input
Output
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as an event of
Disease
Name Identifier Synonyms
disease by infectious agent DOID:0050117 infectious disease
Authored
Gillespie, ME  (2018-10-03)
Reviewed
Streblow, DN  (2019-10-18)
Caposio, P  (2019-10-18)
Created
Gillespie, ME  (2018-10-06)
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