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Assembly of the HCMV Genome DNA Replication Complex
Stable Identifier
R-HSA-9698927
Type
Reaction [binding]
Species
Homo sapiens
Related Species
Human cytomegalovirus
Compartment
nucleoplasm
ReviewStatus
5/5
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Disease (Homo sapiens)
Infectious disease (Homo sapiens)
Viral Infection Pathways (Homo sapiens)
HCMV Infection (Homo sapiens)
HCMV Late Events (Homo sapiens)
Assembly of the HCMV Genome DNA Replication Complex (Homo sapiens)
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During late stages of Human Cytomegalovirus (HCMV) infection viral DNA replication is established. Viral Proteins, UL36, UL49, UL80, UL100, UL117, UL112-UL113, and TRS1 all play a role in DNA replication. UL76 was found to modulate the expression of the essential protein UL77 possibly as part of a mechanism to modulate UL77 levels required for efficient viral replication. Furthermore UL55 and UL76 were found to inhibit DNA replication suggesting that these viral factors are likely key proteins to fine-tune the replication process.
Literature References
PubMed ID
Title
Journal
Year
Fields Virology
Knipe, DM
,
Howley, PM
2013
Participants
Input
Heterotrimeric Helicase-primase [nucleoplasm]
(Human cytomegalovirus)
Human herpesvirus 5 Genome - Merlin Strain [nucleoplasm]
(Human cytomegalovirus)
ppUL84:IE2-p86 [nucleoplasm]
(Human cytomegalovirus)
UL112/UL113 [nucleoplasm]
(Human cytomegalovirus)
Output
HCMV Genome DNA Synthesis Initiation Complex [nucleoplasm]
(Human cytomegalovirus)
Participates
as an event of
HCMV Late Events (Homo sapiens)
Disease
Name
Identifier
Synonyms
disease by infectious agent
DOID:0050117
infectious disease
Authored
Gillespie, ME (2018-10-03)
Reviewed
Streblow, DN (2019-10-18)
Caposio, P (2019-10-18)
Created
Gillespie, ME (2018-10-06)
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