A non-infectious B capsid aquires both tegument and transport protein in the nucleus. A putative capsid vertex capping complex (CVC), composed of UL77 (CVC1) and UL93 (CVC2) proteins, decorates penton tips, and the UL51 and UL52 proteins are added to provide capsid stability. The order of addition of capsid vertex and stabilizing proteins (UL77, UL93, UL51, and UL52) remains to be established. It is not yet resolved whether these proteins are to be considered components of the capsid or tegument. The most capsid-proximal major tegument protein in HCMV is the UL32 protein, pp150, added to nucleocapsids in the nucleus and accompanying maturing particles to the cytoplasm. The pp150 and ppUL96 proteins stabilize nucleocapsids in a common pathway of translocation to cytoplasmic sites of envelopment.
Knipe, DM, Howley, PM
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