The 110 kDa catalytic subunit of PI3K is recruited to the activated FLT3 receptor through interaction with the p85 regulatory subunit. GAB2-mediated conformational changes in the p85 regulatory subunit stimulate interaction with p110, and promote PI3K/AKT signaling downstream of the activated FLT3 receptor (Zhang et al, 1999; Zhang et al, 2000; Masson et al, 2009; Mandelker et al, 2009; Burke et al, 2011; reviewed in Kazi and Ronnstrand, 2019).
Zhang, S, Broxmeyer, HE
Kazi, JU, Rönnstrand, L
Masson, K, Sun, J, Khan, R, Liu, T, Rönnstrand, L
Vadas, O, Burke, JE, Finegan, T, Williams, RL, Perisic, O, Berndt, A
Cheong, I, Mandelker, D, Zhu, J, Schmidt-Kittler, O, Kinzler, KW, Vogelstein, B, Amzel, LM, Gabelli, SB, Huang, CH
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