Reactome | p-STAT5 binds the CDKN1A gene

p-STAT5 binds the CDKN1A gene

Stable Identifier

R-HSA-9698041

Type

Reaction [binding]

Species

Homo sapiens

Compartment

nucleoplasm

Locations in the PathwayBrowser

Expand all

Disease (Homo sapiens)

- Diseases of signal transduction by growth factor receptors and second messengers (Homo sapiens)
  - FLT3 signaling in disease (Homo sapiens)
    - Signaling by FLT3 ITD and TKD mutants (Homo sapiens)
      - STAT5 activation downstream of FLT3 ITD mutants (Homo sapiens)
        
        p-STAT5 binds the CDKN1A gene (Homo sapiens)
    - Signaling by FLT3 fusion proteins (Homo sapiens)
      - p-STAT5 binds the CDKN1A gene (Homo sapiens)

General

SBML | | PDF

SVG | | PPTX | SBGN

Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

p-STAT5 binds to its cognate sites in the promoter of the CDKN1A gene in a FLT3-ITD-dependent manner as assessed by reporter assay and electrophoretic mobility shift assay (EMSA) (Takahashi et al, 2004).

Literature References

PubMed ID	Title	Journal	Year
15003515	Flt3 mutation activates p21WAF1/CIP1 gene expression through the action of STAT5 Takahashi, S, Harigae, H, Kaku, M, Sasaki, T, Licht, JD	Biochem. Biophys. Res. Commun.	2004

Participants

Input

Output

p-STAT5:CDKN1A gene [nucleoplasm] (Homo sapiens)

Participant Of

hasEvent

Disease

Name	Identifier	Synonyms
cancer	162	malignant tumor, malignant neoplasm, primary cancer

Authored

Rothfels, K (2020-11-06)

Reviewed

Kazi, JU (2020-11-06)

Created

Rothfels, K (2020-08-21)

Cite Us!