p-STAT5 translocates to nucleus downstream of mutant FLT3

Stable Identifier
R-HSA-9698033
Type
Reaction [omitted]
Species
Homo sapiens
Compartment
plasma membrane, nucleoplasm
ReviewStatus
5/5
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p-STAT5 translocates to nucleus downstream of mutant FLT3
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Phosphorylated STAT5 translocates to the nucleus where it promotes transcription of a number of FLT3-dependent promoters (Mizuki et al, 2003; Takahashi et al, 2004; Kim et al, 2005; Nabinger et al, 2013; reviewed in Kazi and Ronnstrand, 2019; Rani and Murphy, 2015). STAT5-dependent transcriptional regulation of downstream targets contributes to hyperproliferation and oncogenesis in a number of cancers (reviewed in Rani and Murphy, 2015).
Literature References
PubMed ID Title Journal Year
31066629 FMS-like Tyrosine Kinase 3/FLT3: From Basic Science to Clinical Implications

Kazi, JU, Rönnstrand, L

Physiol. Rev. 2019
15498859 Pim-1 is up-regulated by constitutively activated FLT3 and plays a role in FLT3-mediated cell survival

Kim, KT, Baird, K, Ahn, JY, Meltzer, P, Lilly, M, Levis, M, Small, D

Blood 2005
12468433 Suppression of myeloid transcription factors and induction of STAT response genes by AML-specific Flt3 mutations

Mizuki, M, Schwäble, J, Steur, C, Choudhary, C, Agrawal, S, Sargin, B, Steffen, B, Matsumura, I, Kanakura, Y, Böhmer, FD, Müller-Tidow, C, Berdel, WE, Serve, H

Blood 2003
23103841 The protein tyrosine phosphatase, Shp2, positively contributes to FLT3-ITD-induced hematopoietic progenitor hyperproliferation and malignant disease in vivo

Nabinger, SC, Li, XJ, Ramdas, B, He, Y, Zhang, X, Zeng, L, Richine, B, Bowling, JD, Fukuda, S, Goenka, S, Liu, Z, Feng, GS, Yu, M, Sandusky, GE, Boswell, HS, Zhang, ZY, Kapur, R, Chan, RJ

Leukemia 2013
15003515 Flt3 mutation activates p21WAF1/CIP1 gene expression through the action of STAT5

Takahashi, S, Harigae, H, Kaku, M, Sasaki, T, Licht, JD

Biochem. Biophys. Res. Commun. 2004
26716518 STAT5 in Cancer and Immunity

Rani, A, Murphy, JJ

J. Interferon Cytokine Res. 2016
Participants
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Output
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as an event of
Disease
Name Identifier Synonyms
cancer DOID:162 malignant tumor, malignant neoplasm, primary cancer
Cross References
Mondo
Authored
Rothfels, K  (2020-11-06)
Reviewed
Kazi, JU  (2020-11-06)
Created
Rothfels, K  (2020-08-21)
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