p-STAT5 dissociates from mutant FLT3

Stable Identifier
R-HSA-9698029
Type
Reaction [dissociation]
Species
Homo sapiens
Compartment
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Phosphorylated STAT5 is released from the receptor to fill its role as a nuclear transcription factor (Mizuki et al, 2003; Takahashi et al, 2004; Kim et al, 2005; Nabinger et al, 2013; reviewed in Murphy and Rani, 2015).

Literature References
PubMed ID Title Journal Year
12468433 Suppression of myeloid transcription factors and induction of STAT response genes by AML-specific Flt3 mutations

Mizuki, M, Schwäble, J, Steur, C, Choudhary, C, Agrawal, S, Sargin, B, Steffen, B, Matsumura, I, Kanakura, Y, Böhmer, FD, Müller-Tidow, C, Berdel, WE, Serve, H

Blood 2003
15498859 Pim-1 is up-regulated by constitutively activated FLT3 and plays a role in FLT3-mediated cell survival

Kim, KT, Baird, K, Ahn, JY, Meltzer, P, Lilly, M, Levis, M, Small, D

Blood 2005
23103841 The protein tyrosine phosphatase, Shp2, positively contributes to FLT3-ITD-induced hematopoietic progenitor hyperproliferation and malignant disease in vivo

Nabinger, SC, Li, XJ, Ramdas, B, He, Y, Zhang, X, Zeng, L, Richine, B, Bowling, JD, Fukuda, S, Goenka, S, Liu, Z, Feng, GS, Yu, M, Sandusky, GE, Boswell, HS, Zhang, ZY, Kapur, R, Chan, RJ

Leukemia 2013
15003515 Flt3 mutation activates p21WAF1/CIP1 gene expression through the action of STAT5

Takahashi, S, Harigae, H, Kaku, M, Sasaki, T, Licht, JD

Biochem. Biophys. Res. Commun. 2004
26716518 STAT5 in Cancer and Immunity

Rani, A, Murphy, JJ

J. Interferon Cytokine Res. 2016
Participants
Participant Of
Normal reaction
Disease
Name Identifier Synonyms
cancer 162 malignant tumor, malignant neoplasm, primary cancer
Authored
Reviewed
Created
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