FLT3 ITD- and STAT5-dependent BCL2L1 gene expression

Stable Identifier
R-HSA-9698026
Type
Reaction [omitted]
Species
Homo sapiens
Compartment
nucleoplasm, cytosol
ReviewStatus
5/5
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FLT3 ITD- and STAT5-dependent BCL2L1 gene expression
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FLT3-ITD mutant cells express BCL2L1 in a STAT5 and PTPN11-dependent manner, contributing to hyperproliferation and survival (Nabinger et al, 2013).
Literature References
PubMed ID Title Journal Year
23103841 The protein tyrosine phosphatase, Shp2, positively contributes to FLT3-ITD-induced hematopoietic progenitor hyperproliferation and malignant disease in vivo

Boswell, HS, Ramdas, B, Feng, GS, Zeng, L, Kapur, R, He, Y, Liu, Z, Zhang, X, Sandusky, GE, Zhang, ZY, Fukuda, S, Li, XJ, Nabinger, SC, Yu, M, Richine, B, Chan, RJ, Goenka, S, Bowling, JD

Leukemia 2013
Participants
Input
Output
Participates
as an event of
This event is regulated
Positively by
Regulator
BCL2L1 gene:PTPN11:p-STAT5 [nucleoplasm] (Homo sapiens)
Active Unit
PTPN11:p-STAT5 [nucleoplasm]
Disease
Name Identifier Synonyms
cancer DOID:162 malignant tumor, malignant neoplasm, primary cancer
Authored
Rothfels, K  (2020-11-06)
Reviewed
Kazi, JU  (2020-11-06)
Created
Rothfels, K  (2020-08-21)
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