GAB2 is phosphorylated by the activated FLT3 receptor. Phosphorylated GAB2 interacts with PTPN11 and the regulatory subunit of PI3K and promotes signaling through AKT and STAT5 (Zhang et al, 2000; Masson et al, 2009; Chonabayashi et al, 2013; reviewed in Kazi and Ronnstrand, 2019).
Masson, K, Sun, J, Khan, R, Liu, T, Rönnstrand, L
Kazi, JU, Rönnstrand, L
Zhang, S, Broxmeyer, HE
Ishikawa, T, Kawamata, S, Ohno, T, Chonabayashi, K, Hishizawa, M, Uchiyama, T, Nagai, Y, Takaori-Kondo, A
protein tyrosine kinase activity of p-6Y FLT3 mutant dimers:GRB2:GAB2 [plasma membrane]
Gain of function of p-6Y FLT3 mutant dimers:GRB2:GAB2 [plasma membrane]
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