FLT3 mutants phosphorylate GAB2

Stable Identifier
R-HSA-9698003
Type
Reaction [transition]
Species
Homo sapiens
Compartment
plasma membrane, cytosol
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FLT3 mutants phosphorylate GAB2
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GAB2 is phosphorylated by the activated FLT3 receptor. Phosphorylated GAB2 interacts with PTPN11 and the regulatory subunit of PI3K and promotes signaling through AKT and STAT5 (Zhang et al, 2000; Masson et al, 2009; Chonabayashi et al, 2013; reviewed in Kazi and Ronnstrand, 2019).

Literature References
PubMed ID Title Journal Year
23168613 Direct binding of Grb2 has an important role in the development of myeloproliferative disease induced by ETV6/FLT3

Ishikawa, T, Kawamata, S, Ohno, T, Chonabayashi, K, Hishizawa, M, Uchiyama, T, Nagai, Y, Takaori-Kondo, A

Leukemia 2013
31066629 FMS-like Tyrosine Kinase 3/FLT3: From Basic Science to Clinical Implications

Kazi, JU, Rönnstrand, L

Physiol. Rev. 2019
19438505 A role of Gab2 association in Flt3 ITD mediated Stat5 phosphorylation and cell survival

Masson, K, Sun, J, Khan, R, Liu, T, Rönnstrand, L

Br. J. Haematol. 2009
11027663 Flt3 ligand induces tyrosine phosphorylation of gab1 and gab2 and their association with shp-2, grb2, and PI3 kinase

Zhang, S, Broxmeyer, HE

Biochem. Biophys. Res. Commun. 2000
Participants
Input
Output
Participates
as an event of
Catalyst Activity

protein tyrosine kinase activity of p-6Y FLT3 mutant dimers:GRB2:GAB2 [plasma membrane]

Physical Entity
p-6Y FLT3 mutant dimers:GRB2:GAB2 [plasma membrane] (Homo sapiens)
Activity
protein tyrosine kinase activity (GO:0004713)
Normal reaction
GAB2 in Active FLT3:GRB2:GAB2 is phosphorylated (Homo sapiens)
Functional status

Gain of function of p-6Y FLT3 mutant dimers:GRB2:GAB2 [plasma membrane]

Normal Entity
Disease Entity
Status
Disease
Name Identifier Synonyms
cancer DOID:162 malignant tumor, malignant neoplasm, primary cancer
Authored
Rothfels, K  (2020-11-06)
Reviewed
Kazi, JU  (2020-11-06)
Created
Rothfels, K  (2020-08-21)
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