GAB2 is phosphorylated by the activated FLT3 receptor. Phosphorylated GAB2 interacts with PTPN11 and the regulatory subunit of PI3K and promotes signaling through AKT and STAT5 (Zhang et al, 2000; Masson et al, 2009; Chonabayashi et al, 2013; reviewed in Kazi and Ronnstrand, 2019).
Kazi, JU, Rönnstrand, L
Masson, K, Liu, T, Khan, R, Sun, J, Rönnstrand, L
Zhang, S, Broxmeyer, HE
Chonabayashi, K, Hishizawa, M, Kawamata, S, Nagai, Y, Ohno, T, Ishikawa, T, Uchiyama, T, Takaori-Kondo, A
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