FLT3 mutants phosphorylate GAB2

Stable Identifier
R-HSA-9698003
Type
Reaction [transition]
Species
Homo sapiens
Compartment
plasma membrane, cytosol
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FLT3 mutants phosphorylate GAB2
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GAB2 is phosphorylated by the activated FLT3 receptor. Phosphorylated GAB2 interacts with PTPN11 and the regulatory subunit of PI3K and promotes signaling through AKT and STAT5 (Zhang et al, 2000; Masson et al, 2009; Chonabayashi et al, 2013; reviewed in Kazi and Ronnstrand, 2019).

Literature References
PubMed ID Title Journal Year
19438505 A role of Gab2 association in Flt3 ITD mediated Stat5 phosphorylation and cell survival

Masson, K, Sun, J, Khan, R, Liu, T, Rönnstrand, L

Br. J. Haematol. 2009
31066629 FMS-like Tyrosine Kinase 3/FLT3: From Basic Science to Clinical Implications

Kazi, JU, Rönnstrand, L

Physiol. Rev. 2019
11027663 Flt3 ligand induces tyrosine phosphorylation of gab1 and gab2 and their association with shp-2, grb2, and PI3 kinase

Zhang, S, Broxmeyer, HE

Biochem. Biophys. Res. Commun. 2000
23168613 Direct binding of Grb2 has an important role in the development of myeloproliferative disease induced by ETV6/FLT3

Ishikawa, T, Kawamata, S, Ohno, T, Chonabayashi, K, Hishizawa, M, Uchiyama, T, Nagai, Y, Takaori-Kondo, A

Leukemia 2013
Participants
Input
Output
Participates
as an event of
Catalyst Activity

protein tyrosine kinase activity of p-6Y FLT3 mutant dimers:GRB2:GAB2 [plasma membrane]

Physical Entity
p-6Y FLT3 mutant dimers:GRB2:GAB2 [plasma membrane] (Homo sapiens)
Activity
protein tyrosine kinase activity (GO:0004713)
Normal reaction
GAB2 in Active FLT3:GRB2:GAB2 is phosphorylated (Homo sapiens)
Functional status

Gain of function of p-6Y FLT3 mutant dimers:GRB2:GAB2 [plasma membrane]

Normal Entity
Disease Entity
Status
Disease
Name Identifier Synonyms
cancer DOID:162 malignant tumor, malignant neoplasm, primary cancer
Authored
Rothfels, K  (2020-11-06)
Reviewed
Kazi, JU  (2020-11-06)
Created
Rothfels, K  (2020-08-21)
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