GRB2 recruits the adaptor GAB2 to activated FLT3 receptors (Zhang et al, 2000; Masson et al, 2009; Chonabayashi et al, 2013). Subsequent receptor-mediated phosphorylation of GAB2 results in recruitment of PI3K and PTPN11, leading to AKT and STAT signaling (Zhang et al, 2000; Masson et al, 2009; reviewed in Kazi and Ronnstrand, 2019). Activation of these pathways is more pronounced in ITD-containing FLT receptors than those bearing activating point mutations (reviewed in Kazi and Ronnstrand, 2019).
Kazi, JU, Rönnstrand, L
Masson, K, Liu, T, Khan, R, Sun, J, Rönnstrand, L
Zhang, S, Broxmeyer, HE
Chonabayashi, K, Hishizawa, M, Kawamata, S, Nagai, Y, Ohno, T, Ishikawa, T, Uchiyama, T, Takaori-Kondo, A
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