FLT3 mutants:GRB2 bind GAB2

Stable Identifier
R-HSA-9698000
Type
Reaction [binding]
Species
Homo sapiens
Compartment
plasma membrane, cytosol
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FLT3 mutants:GRB2 bind GAB2
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GRB2 recruits the adaptor GAB2 to activated FLT3 receptors (Zhang et al, 2000; Masson et al, 2009; Chonabayashi et al, 2013). Subsequent receptor-mediated phosphorylation of GAB2 results in recruitment of PI3K and PTPN11, leading to AKT and STAT signaling (Zhang et al, 2000; Masson et al, 2009; reviewed in Kazi and Ronnstrand, 2019). Activation of these pathways is more pronounced in ITD-containing FLT receptors than those bearing activating point mutations (reviewed in Kazi and Ronnstrand, 2019).

Literature References
PubMed ID Title Journal Year
19438505 A role of Gab2 association in Flt3 ITD mediated Stat5 phosphorylation and cell survival

Masson, K, Sun, J, Khan, R, Liu, T, Rönnstrand, L

Br. J. Haematol. 2009
31066629 FMS-like Tyrosine Kinase 3/FLT3: From Basic Science to Clinical Implications

Kazi, JU, Rönnstrand, L

Physiol. Rev. 2019
11027663 Flt3 ligand induces tyrosine phosphorylation of gab1 and gab2 and their association with shp-2, grb2, and PI3 kinase

Zhang, S, Broxmeyer, HE

Biochem. Biophys. Res. Commun. 2000
23168613 Direct binding of Grb2 has an important role in the development of myeloproliferative disease induced by ETV6/FLT3

Ishikawa, T, Kawamata, S, Ohno, T, Chonabayashi, K, Hishizawa, M, Uchiyama, T, Nagai, Y, Takaori-Kondo, A

Leukemia 2013
Participants
Input
Output
Participates
as an event of
Normal reaction
Active FLT3:GRB2 binds GAB2 (Homo sapiens)
Functional status

Gain of function of p-6Y FLT3 mutant dimers:GRB2 [plasma membrane]

Normal Entity
Disease Entity
Status
Disease
Name Identifier Synonyms
cancer DOID:162 malignant tumor, malignant neoplasm, primary cancer
Authored
Rothfels, K  (2020-11-06)
Reviewed
Kazi, JU  (2020-11-06)
Created
Rothfels, K  (2020-08-21)
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