Rifampicin binds Mtb RNAP

Stable Identifier
R-HSA-9697086
Type
Reaction [binding]
Species
Homo sapiens
Related Species
Mycobacterium tuberculosis
Compartment
cytosol
ReviewStatus
5/5
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Rifampicin binds Mtb RNAP
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The core of the bacterial RNA polymerase (RNAP) consists of 5 subunits and is highly conserved across the kingdom. The antimycobacterial drug rifampicin binds to the rpoB subunit and inhibits transcription (Wehrli et al. 1968, Heil & Zillig 1970).
Literature References
PubMed ID Title Journal Year
4879400 Interaction of rifamycin with bacterial RNA polymerase

Knüsel, F, Staehelin, M, Wehrli, W, Schmid, K

Proc. Natl. Acad. Sci. U.S.A. 1968
11945477 Reconstitution of bacterial DNA-dependent RNA-polymerase from isolated subunits as a tool for the elucidation of the role of the subunits in transcription

Zillig, W, Heil, A

FEBS Lett. 1970
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Disease
Name Identifier Synonyms
tuberculosis DOID:399 tuberculous abscess, Tuberculoma (finding), tuberculoma
Authored
Stephan, R  (2019-03-06)
Reviewed
Wilkinson, RJ  (2019-10-23)
Deffur, A  (2019-10-23)
Created
Jassal, B  (2020-08-05)
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