EsxG binds esxH

Stable Identifier
R-HSA-9697057
Type
Reaction [binding]
Species
Homo sapiens
Related Species
Mycobacterium tuberculosis
Compartment
cytosol
ReviewStatus
5/5
Locations in the PathwayBrowser
Expand all
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
EsxG binds esxH
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout
ESAT-6-like proteins EsxG and EsxH form a stable 1:1 heterodimeric complex. The structure of the complex consists of a four-helix bundle with flexible N- and C-terminal arms (Lightbody et al. 2004, Ilghari et al. 2011).
Literature References
PubMed ID Title Journal Year
21730061 Solution structure of the Mycobacterium tuberculosis EsxG·EsxH complex: functional implications and comparisons with other M. tuberculosis Esx family complexes

Ilghari, D, Lightbody, KL, Veverka, V, Waters, LC, Muskett, FW, Renshaw, PS, Carr, MD

J. Biol. Chem. 2011
15336430 Characterisation of complex formation between members of the Mycobacterium tuberculosis complex CFP-10/ESAT-6 protein family: towards an understanding of the rules governing complex formation and thereby functional flexibility

Lightbody, KL, Renshaw, PS, Collins, ML, Wright, RL, Hunt, DM, Gordon, SV, Hewinson, RG, Buxton, RS, Williamson, RA, Carr, MD

FEMS Microbiol. Lett. 2004
Participants
Input
Output
Participates
as an event of
Disease
Name Identifier Synonyms
tuberculosis DOID:399 tuberculous abscess, Tuberculoma (finding), tuberculoma
Cross References
Mondo
Authored
Stephan, R  (2019-02-06)
Reviewed
Deffur, A  (2019-10-23)
Wilkinson, RJ  (2019-10-23)
Created
Jassal, B  (2020-08-05)
Cite Us!