Addition of sialic acids on some Spike glycosyl sidechains

Stable Identifier
R-HSA-9697018
Type
Reaction [uncertain]
Species
Homo sapiens
Related Species
Severe acute respiratory syndrome coronavirus 2
Compartment
endoplasmic reticulum-Golgi intermediate compartment
ReviewStatus
5/5
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Addition of sialic acids on some Spike glycosyl sidechains
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Glycosyl sidechains at Asn-1158 and Asn-1194 are sialylated, presumably by the cell's sialyltransferases (Watanabe et al, 2020).
Literature References
PubMed ID Title Journal Year
32366695 Site-specific glycan analysis of the SARS-CoV-2 spike

Watanabe, Y, Allen, JD, Wrapp, D, McLellan, JS, Crispin, M

Science 2020
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Input
Output
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as an event of
Catalyst Activity

sialyltransferase activity of sialyltransferases

Physical Entity
sialyltransferases [Golgi membrane] (Homo sapiens)
Activity
sialyltransferase activity (GO:0008373)
Disease
Name Identifier Synonyms
COVID-19 DOID:0080600 2019 Novel Coronavirus (2019-nCoV), Wuhan seafood market pneumonia virus infection, 2019-nCoV infection, Wuhan coronavirus infection
Cross References
Mondo
Authored
Stephan, R  (2020-07-30)
Reviewed
Acencio, ML  (2020-09-09)
Created
Stephan, R  (2020-08-04)
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