Spike trimer glycoside chains get additional branches

Stable Identifier
R-HSA-9696980
Type
Reaction [uncertain]
Species
Homo sapiens
Related Species
Severe acute respiratory syndrome coronavirus 2
Compartment
endoplasmic reticulum-Golgi intermediate compartment
ReviewStatus
5/5
Locations in the PathwayBrowser
Expand all
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
Spike trimer glycoside chains get additional branches
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout
Nearly all di-antennary N-glycan sidechains of Spike get further extended to tri-antennary configuration by addition of fucose and further N-acetylglucosamine moieties. Asn-1158 is probably an exception, it stays di-antennary (Watanabe et al, 2020).
Literature References
PubMed ID Title Journal Year
32366695 Site-specific glycan analysis of the SARS-CoV-2 spike

Watanabe, Y, Crispin, M, Allen, JD, McLellan, JS, Wrapp, D

Science 2020
Participants
Input
Output
Participates
as an event of
Catalyst Activity

alpha-1,3-mannosylglycoprotein 4-beta-N-acetylglucosaminyltransferase activity of MGAT4s [Golgi membrane]

Physical Entity
MGAT4s [Golgi membrane] (Homo sapiens)
Activity
alpha-1,3-mannosylglycoprotein 4-beta-N-acetylglucosaminyltransferase activity (GO:0008454)

glycoprotein 6-alpha-L-fucosyltransferase activity of FUT8 [Golgi membrane]

Physical Entity
FUT8 [Golgi membrane] (Homo sapiens)
Activity
glycoprotein 6-alpha-L-fucosyltransferase activity (GO:0008424)

alpha-1,6-mannosylglycoprotein 6-beta-N-acetylglucosaminyltransferase activity of MGAT5 [Golgi membrane]

Physical Entity
MGAT5 [Golgi membrane] (Homo sapiens)
Activity
alpha-1,6-mannosylglycoprotein 6-beta-N-acetylglucosaminyltransferase activity (GO:0030144)
Disease
Name Identifier Synonyms
COVID-19 DOID:0080600 2019 Novel Coronavirus (2019-nCoV), Wuhan seafood market pneumonia virus infection, 2019-nCoV infection, Wuhan coronavirus infection
Reviewed
Acencio, ML  (2020-09-09)
Created
Stephan, R  (2020-08-04)
Cite Us!