Reactome | RND2 GTPase cycle

RND2 GTPase cycle

Stable Identifier

R-HSA-9696270

Type

Pathway

Species

Homo sapiens

ReviewStatus

5/5

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RND2 (RHON) is an atypical RHO GTPase and the least studied member of the RND subfamily. RND2 is constitutively bound to GTP and lacks GTPase activity. No guanine nucleotide exchange factors (GEFs), GTPase activator proteins (GAPs) or guanine nucleotide dissociation inhibitors (GDIs) act on RND2. RND2 is predominantly expressed in brain, testis and liver (Nobes et al. 1998; Nishi et al. 1999). RND2 regulates neurite outgrowth and branching (Fujita et al. 2002; Kakimoto et al. 2004; Tanaka et al. 2006; Wakita et al. 2011) and migration of newborn neurons within the embryonic cerebral cortex (Nakamura et al. 2006; Heng et al. 2008; Alfano et al. 2011; Pacary et al. 2011; Gladwyn-Ng et al. 2015; Heng et al. 2015).

Literature References

PubMed ID	Title	Journal	Year
16481321	Pragmin, a novel effector of Rnd2 GTPase, stimulates RhoA activity Katoh, H, Tanaka, H, Negishi, M	J. Biol. Chem.	2006
18690213	Neurogenin 2 controls cortical neuron migration through regulation of Rnd2 Bedogni, F, Wildner, H, Zimmer, C, Castro, DS, Nguyen, L, Matter, JM, Skowronska-Krawczyk, D, Guillemot, F, Armant, O, Hevner, R, Heng, JI	Nature	2008
10101234	RhoN, a novel small GTP-binding protein expressed predominantly in neurons and hepatic stellate cells Takeshima, H, Sugimoto, T, Noda, T, Nishi, M, Nakagawara, K, Houtani, T	Brain Res. Mol. Brain Res.	1999
21435554	Proneural transcription factors regulate different steps of cortical neuron migration through Rnd-mediated inhibition of RhoA signaling Ridley, AJ, Heng, J, Lebel-Potter, M, Bell, DM, Azzarelli, R, Castro, D, Parsons, M, Pacary, E, Guillemot, F, Parras, C, Riou, P	Neuron	2011
12244061	Rapostlin is a novel effector of Rnd2 GTPase inducing neurite branching Fujita, H, Katoh, H, Mori, K, Negishi, M, Ishikawa, Y	J. Biol. Chem.	2002
9531558	A new member of the Rho family, Rnd1, promotes disassembly of actin filament structures and loss of cell adhesion Chardin, P, Nobes, CD, Lauritzen, I, Hall, A, Paris, S, Mattei, MG	J. Cell Biol.	1998
14732713	Identification of splicing variants of Rapostlin, a novel RND2 effector that interacts with neural Wiskott-Aldrich syndrome protein and induces neurite branching Kakimoto, T, Katoh, H, Negishi, M	J. Biol. Chem.	2004
24084125	The zinc finger transcription factor RP58 negatively regulates Rnd2 for the control of neuronal migration during cerebral cortical development Kasai, M, Qu, Z, Ohtaka-Maruyama, C, Castro, D, Guillemot, F, Tan, SS, Okado, H, Heng, JI	Cereb. Cortex	2015
16303198	In vivo function of Rnd2 in the development of neocortical pyramidal neurons Katoh, H, Tamamaki, N, Kaneko, T, Yamashita, Y, Negishi, M, Nakamura, K	Neurosci. Res.	2006
21768103	The F-BAR protein Rapostlin regulates dendritic spine formation in hippocampal neurons Kakimoto, T, Katoh, H, Wakita, Y, Negishi, M	J. Biol. Chem.	2011
25888806	Bacurd2 is a novel interacting partner to Rnd2 which controls radial migration within the developing mammalian cerebral cortex Qu, Z, Ngo, L, Gladwyn-Ng, IE, Davis, JM, Li, SS, Singer, J, Haas, M, Heng, JI	Neural Dev	2015
21965613	COUP-TFI promotes radial migration and proper morphology of callosal projection neurons by repressing Rnd2 expression De Maio, A, Alfano, C, Pirozzi, M, Flore, G, Studer, M, Viola, L, Guillemot, F, Clarkson, M, Schedl, A, Heng, JI	Development	2011