Reactome | RND2 binds effectors

RND2 binds effectors

Stable Identifier

R-HSA-9696266

Type

Reaction [binding]

Species

Homo sapiens

Compartment

cytosol, plasma membrane

ReviewStatus

5/5

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General

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Active GTP bound RND2 binds the following effectors:
ARHGAP5 (Wennerberg et al. 2003; Bagi et al. 2020)
FNBP1 (Fujita et al. 2002; Kakimoto et al. 2004; Bagci et al. 2020)
FRS2 (Harada et al. 2005)
FRS3 (Harada et al. 2005)
KCTD13 (Gladwyn Ng et al. 2016)
PLXND1 (Uesugi et al. 2009)
PRAG1 (Tanaka et al. 2006)
TNFAIP1 (Gladwyn Ng et al. 2015; Gladwyn Ng et al. 2016)
UBXN11 (Katoh et al. 2002)

RND2 binds to the following candidate effectors reported in the high throughput screen by Bagci et al. 2020 or reported in some but all studies:
ALDH3A2 (Bagci et al. 2020)
ANKRD26 (Bagci et al. 2020)
ARHGAP1 (Bagci et al. 2020)
ARHGAP35 (Wennerberg et al. 2003: binding to active RND2; Bagci et al. 2020: no binding to active RND2)
CAV1 (Bagci et al. 2020)
CKAP4 (Bagci et al. 2020)
DEPDC1B (Bagci et al. 2020)
DLG5 (Bagci et al. 2020)
DSG1 (Bagci et al. 2020)
DST (Bagci et al. 2020)
EPHA2 (Bagci et al. 2020)
FAM83B (Bagci et al. 2020)
GOLGA3 (Bagci et al. 2020)
KIDINS220 (Bagci et al. 2020)
KIF14 (Bagci et al. 2020)
KTN1 (Bagci et al. 2020) - while RND2 has not been shown to localize to the endoplasmic reticulum membrane (ER), some isoforms of KTN1 are known to localize to the plasma membrane instead of the ER membrane (Santama et al. 2004)
LEMD3 (Bagci et al. 2020)
LRRC1 (Bagci et al. 2020)
MUC13 (Bagci et al. 2020)
NISCH (Bagci et al. 2020)
NUDC (Bagci et al. 2020)
PIK3R1 (Bagci et al. 2020)
PIK3R2 (Bagci et al. 2020)
PKP4 (Bagci et al. 2020)
PTPN13 (Bagci et al. 2020)
RBMX (Bagci et al. 2020)
SCRIB (Bagci et al. 2020)
TFRC (Bagci et al. 2020)
TXNL1 (Bagci et al. 2020)
UHRF1BP1L (Bagci et al. 2020)
VANGL1 (Bagci et al. 2020)
VANGL2 (Bagci et al. 2020)
WDR6 (Bagci et al. 2020)

RND2 does not bind the following effectors:
CCDC88A (Bagci et al. 2020)
CKB (Bagci et al. 2020)
CPD (Bagci et al. 2020)
DDX4 (Bagci et al. 2020)
DSP (Bagci et al. 2020)
EPSTI1 (Bagci et al. 2020)
FAM135A (Bagci et al. 2020)
FLOT2 (Bagci et al. 2020)
GRB7 (Vayssiere et al. 2000)
PLEKHG5 (Goh and Manser 2010)
PICALM (Bagci et al. 2020)
RASAL2 (Bagci et al. 2020)
RRAS2 (Bagci et al. 2020)
SEMA4F (Bagci et al. 2020)
STIP1 (de Souza et al. 2014)
STMN2 (Li et al. 2009)
TMEM59 (Bagci et al. 2020)
TMOD3 (Bagci et al. 2020)

Literature References

PubMed ID	Title	Journal	Year
15738000	Direct interaction of Rnd1 with FRS2 beta regulates Rnd1-induced down-regulation of RhoA activity and is involved in fibroblast growth factor-induced neurite outgrowth in PC12 cells Harada, A, Katoh, H, Negishi, M	J. Biol. Chem.	2005
11940653	Socius is a novel Rnd GTPase-interacting protein involved in disassembly of actin stress fibers Harada, A, Katoh, H, Mori, K, Negishi, M	Mol. Cell. Biol.	2002
14732713	Identification of splicing variants of Rapostlin, a novel RND2 effector that interacts with neural Wiskott-Aldrich syndrome protein and induces neurite branching Kakimoto, T, Katoh, H, Negishi, M	J. Biol. Chem.	2004
20811643	The RhoA GEF Syx is a target of Rnd3 and regulated via a Raf1-like ubiquitin-related domain Goh, LL, Manser, E	PLoS ONE	2010
18996843	Rnd1 regulates axon extension by enhancing the microtubule destabilizing activity of SCG10 Ghavampur, S, Li, YH, Grenningloh, G, Bondallaz, P, Püschel, AW, Will, L	J. Biol. Chem.	2009
12842009	Rnd proteins function as RhoA antagonists by activating p190 RhoGAP Burridge, K, Ellerbroek, SM, Forget, MA, Settleman, J, Arthur, WT, Wennerberg, K, Hansen, SH, Der, CJ	Curr. Biol.	2003
24690281	STI1 antagonizes cytoskeleton collapse mediated by small GTPase Rnd1 and regulates neurite growth Nakao, LS, Lopes, MH, Mercadante, AF, Püschel, AW, Martins, VR, Zanata, SM, de Souza, LE, Bilek, ES, Moura Costa, MD	Exp. Cell Res.	2014
16481321	Pragmin, a novel effector of Rnd2 GTPase, stimulates RhoA activity Katoh, H, Tanaka, H, Negishi, M	J. Biol. Chem.	2006
26969432	Bacurd1/Kctd13 and Bacurd2/Tnfaip1 are interacting partners to Rnd proteins which influence the long-term positioning and dendritic maturation of cerebral cortical neurons Qu, Z, Ngo, L, Huang, L, Vanyai, HK, Cullen, HD, Davis, JM, Li, SS, Gladwyn-Ng, I, Heng, JI	Neural Dev	2016
12244061	Rapostlin is a novel effector of Rnd2 GTPase inducing neurite branching Fujita, H, Katoh, H, Mori, K, Negishi, M, Ishikawa, Y	J. Biol. Chem.	2002
19136556	Different requirement for Rnd GTPases of R-Ras GAP activity of Plexin-C1 and Plexin-D1 Katoh, H, Uesugi, K, Oinuma, I, Negishi, M	J Biol Chem	2009
31871319	Mapping the proximity interaction network of the Rho-family GTPases reveals signalling pathways and regulatory mechanisms Tran, V, Gingras, AC, Elkholi, IE, Robert, A, Boulais, J, Faubert, D, Dubé, N, Hipfner, DR, Cote, JF, Lin, ZY, Bagci, H, Sriskandarajah, N, Thibault, MP	Nat. Cell Biol.	2020
25888806	Bacurd2 is a novel interacting partner to Rnd2 which controls radial migration within the developing mammalian cerebral cortex Qu, Z, Ngo, L, Gladwyn-Ng, IE, Davis, JM, Li, SS, Singer, J, Haas, M, Heng, JI	Neural Dev	2015
10664463	Interaction of the Grb7 adapter protein with Rnd1, a new member of the Rho family Mirey, G, Chardin, P, Camonis, J, Zalcman, G, Vayssière, B, Ligensa, T, Weidner, KM, Mahé, Y	FEBS Lett.	2000