Reactome | SPHK2 phosphorylates sphingoid

SPHK2 phosphorylates sphingoid

Stable Identifier

R-HSA-9695949

Type

Reaction [transition]

Species

Homo sapiens

Compartment

cytosol, endoplasmic reticulum membrane

ReviewStatus

5/5

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The cytosolic enzyme sphingosine kinase 2 (SPHK2) catalyzes the phosphorylation of sphingoids (SPG) to sphingoid 1-phosphate (S1P). The main product is sphingosine 1-phosphate, a bioactive lipid that acts extracellularly on G protein-coupled receptors of the S1P1/EDG-1 subfamily (Liu et al., 2000; reviewed by Siow & Wattenberg, 2011). Through alternative splicing, the isoforms of SK2a and SK2b are produced that show functional differences in their activity (reviewed by Hatoum et al., 2017). In contrast to pro-survival SPHK1, the BH3-only protein SPHK2 inhibits cell growth and enhances apoptosis (Maceyka et al., 2005).

Literature References

PubMed ID	Title	Journal	Year
28415564	Mammalian sphingosine kinase (SphK) isoenzymes and isoform expression: challenges for SphK as an oncotarget Hatoum, D, Haddadi, N, Lin, Y, Nassif, NT, McGowan, EM	Oncotarget	2017
16118219	SphK1 and SphK2, sphingosine kinase isoenzymes with opposing functions in sphingolipid metabolism Maceyka, M, Sankala, H, Hait, NC, Le Stunff, H, Liu, H, Toman, R, Collier, C, Zhang, M, Satin, LS, Merrill, AH, Milstien, S, Spiegel, S	J. Biol. Chem.	2005
10751414	Molecular cloning and functional characterization of a novel mammalian sphingosine kinase type 2 isoform Liu, H, Sugiura, M, Nava, VE, Edsall, LC, Kono, K, Poulton, S, Milstien, S, Kohama, T, Spiegel, S	J Biol Chem	2000
21864225	The compartmentalization and translocation of the sphingosine kinases: mechanisms and functions in cell signaling and sphingolipid metabolism Siow, D, Wattenberg, B	Crit Rev Biochem Mol Biol	2011