Reactome | SPNS2,MFSD2B transport S1P from cytosol to extracellular region

SPNS2,MFSD2B transport S1P from cytosol to extracellular region

Stable Identifier

R-HSA-9695890

Type

Reaction [transition]

Species

Homo sapiens

Compartment

cytosol, extracellular region, plasma membrane

ReviewStatus

5/5

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SPNS2,MFSD2B transport S1P from cytosol to extracellular region

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Several different transporters catalyze the secretion of sphingosine 1-phosphate (S1P). S1P is a signaling molecule that regulates many physiological processes in development and the immune system. S1P is produced inside cells, so it must be secreted to exert its effects through its receptors. Protein spinster homolog 2 (SPNS2) is an S1P transporter involved in S1P secretion and regulation of its levels in the lymph, thereby playing a role in lymphocyte trafficking (Nagahashi et al., 2013; Chen et al., 2023; reviewed by Spiegel et al., 2019). MFSD2A exports S1P and is mainly expressed in erythrocytes and platelets, having the function, together with SPNS2, of maintaining the blood-brain barrier (Kobayashi et al., 2018; reviewed by Ghaderi & Levkau, 2023). There is evidence in rats of S1P export by rat homologs of ABCA1, ABCA7, and ABCC1 (reviewed by Reitsema et al., 2014).

Literature References

PubMed ID	Title	Journal	Year
37390971	An erythrocyte-centric view on the MFSD2B sphingosine-1-phosphate transporter Ghaderi, S, Levkau, B	Pharmacol Ther	2023
29563527	MFSD2B is a sphingosine 1-phosphate transporter in erythroid cells Kobayashi, N, Kawasaki-Nishi, S, Otsuka, M, Hisano, Y, Yamaguchi, A, Nishi, T	Sci Rep	2018
	Sphingosine-1-phosphate transport and its role in immunology Reitsema, V, Bouma, H, Kok, JW
23180825	Spns2, a transporter of phosphorylated sphingoid bases, regulates their blood and lymph levels, and the lymphatic network Nagahashi, M, Kim, EY, Yamada, A, Ramachandran, S, Allegood, JC, Hait, NC, Maceyka, M, Milstien, S, Takabe, K, Spiegel, S	FASEB J.	2013
37224812	Structural and functional insights into Spns2-mediated transport of sphingosine-1-phosphate Chen, H, Ahmed, S, Zhao, H, Elghobashi-Meinhardt, N, Dai, Y, Kim, JH, McDonald, JG, Li, X, Lee, CH	Cell	2023
30655317	New insights into functions of the sphingosine-1-phosphate transporter SPNS2 Spiegel, S, Maczis, MA, Maceyka, M, Milstien, S	J Lipid Res	2019