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p-6Y FLT3 extracellular domain, kinase domain and juxtamembrane domain mutant dimers [plasma membrane]
Stable Identifier
R-HSA-9695782
Type
Set [DefinedSet]
Species
Homo sapiens
Compartment
plasma membrane
Locations in the PathwayBrowser
Expand all
Disease (Homo sapiens)
Diseases of signal transduction by growth factor receptors and second messengers (Homo sapiens)
FLT3 signaling in disease (Homo sapiens)
Signaling by FLT3 ITD and TKD mutants (Homo sapiens)
Constitutive phosphorylation of FLT3 mutants (Homo sapiens)
p-6Y FLT3 extracellular domain, kinase domain and juxtamembrane domain mutant dimers [plasma membrane] (Homo sapiens)
FLT3 mutant dimers bind GRB2 (Homo sapiens)
p-6Y FLT3 extracellular domain, kinase domain and juxtamembrane domain mutant dimers [plasma membrane] (Homo sapiens)
p-6Y FLT3 mutant dimers:GRB2 [plasma membrane] (Homo sapiens)
p-6Y FLT3 extracellular domain, kinase domain and juxtamembrane domain mutant dimers [plasma membrane] (Homo sapiens)
FLT3 mutant dimers:GRB2 bind SOS1 (Homo sapiens)
p-6Y FLT3 mutant dimers:GRB2 [plasma membrane] (Homo sapiens)
p-6Y FLT3 extracellular domain, kinase domain and juxtamembrane domain mutant dimers [plasma membrane] (Homo sapiens)
p-6Y FLT3 mutant dimers:GRB2:SOS1 [plasma membrane] (Homo sapiens)
p-6Y FLT3 extracellular domain, kinase domain and juxtamembrane domain mutant dimers [plasma membrane] (Homo sapiens)
FLT3 mutants phosphorylate GAB2 (Homo sapiens)
p-6Y FLT3 mutant dimers:GRB2:GAB2 [plasma membrane] (Homo sapiens)
p-6Y FLT3 mutant dimers:GRB2 [plasma membrane] (Homo sapiens)
p-6Y FLT3 extracellular domain, kinase domain and juxtamembrane domain mutant dimers [plasma membrane] (Homo sapiens)
p-6Y FLT3 mutant dimers:GRB2:p-Y GAB2 [plasma membrane] (Homo sapiens)
p-6Y FLT3 mutant dimers:GRB2 [plasma membrane] (Homo sapiens)
p-6Y FLT3 extracellular domain, kinase domain and juxtamembrane domain mutant dimers [plasma membrane] (Homo sapiens)
FLT3 mutants recruit PIK3CA through PIK3R1 (Homo sapiens)
p-6Y FLT3 ITD mutant dimers:GRB2:p-Y GAB2:PI3K [plasma membrane] (Homo sapiens)
p-6Y FLT3 mutant dimers:GRB2:p-Y GAB2:PIK3R1 [plasma membrane] (Homo sapiens)
p-6Y FLT3 mutant dimers:GRB2:p-Y GAB2 [plasma membrane] (Homo sapiens)
p-6Y FLT3 mutant dimers:GRB2 [plasma membrane] (Homo sapiens)
p-6Y FLT3 extracellular domain, kinase domain and juxtamembrane domain mutant dimers [plasma membrane] (Homo sapiens)
p-6Y FLT3 mutant dimers:GRB2:p-Y GAB2:PIK3R1 [plasma membrane] (Homo sapiens)
p-6Y FLT3 mutant dimers:GRB2:p-Y GAB2 [plasma membrane] (Homo sapiens)
p-6Y FLT3 mutant dimers:GRB2 [plasma membrane] (Homo sapiens)
p-6Y FLT3 extracellular domain, kinase domain and juxtamembrane domain mutant dimers [plasma membrane] (Homo sapiens)
FLT3 mutants recruit PIK3R1 through phosphorylated GAB2 (Homo sapiens)
p-6Y FLT3 mutant dimers:GRB2:p-Y GAB2 [plasma membrane] (Homo sapiens)
p-6Y FLT3 mutant dimers:GRB2 [plasma membrane] (Homo sapiens)
p-6Y FLT3 extracellular domain, kinase domain and juxtamembrane domain mutant dimers [plasma membrane] (Homo sapiens)
p-6Y FLT3 mutant dimers:GRB2:p-Y GAB2:PIK3R1 [plasma membrane] (Homo sapiens)
p-6Y FLT3 mutant dimers:GRB2:p-Y GAB2 [plasma membrane] (Homo sapiens)
p-6Y FLT3 mutant dimers:GRB2 [plasma membrane] (Homo sapiens)
p-6Y FLT3 extracellular domain, kinase domain and juxtamembrane domain mutant dimers [plasma membrane] (Homo sapiens)
FLT3 mutants:GRB2 bind GAB2 (Homo sapiens)
p-6Y FLT3 mutant dimers:GRB2 [plasma membrane] (Homo sapiens)
p-6Y FLT3 extracellular domain, kinase domain and juxtamembrane domain mutant dimers [plasma membrane] (Homo sapiens)
p-6Y FLT3 mutant dimers:GRB2:GAB2 [plasma membrane] (Homo sapiens)
p-6Y FLT3 mutant dimers:GRB2 [plasma membrane] (Homo sapiens)
p-6Y FLT3 extracellular domain, kinase domain and juxtamembrane domain mutant dimers [plasma membrane] (Homo sapiens)
FLT3 mutants:GRB2:SOS1-mediated nucleotide exchange on RAS (Homo sapiens)
p-6Y FLT3 mutant dimers:GRB2:SOS1 [plasma membrane] (Homo sapiens)
p-6Y FLT3 extracellular domain, kinase domain and juxtamembrane domain mutant dimers [plasma membrane] (Homo sapiens)
FLT3 mutants:GRB2:p-Y-GAB2 binds PTPN11 (Homo sapiens)
p-6Y FLT3 mutant dimers:GRB2:p-Y GAB2 [plasma membrane] (Homo sapiens)
p-6Y FLT3 mutant dimers:GRB2 [plasma membrane] (Homo sapiens)
p-6Y FLT3 extracellular domain, kinase domain and juxtamembrane domain mutant dimers [plasma membrane] (Homo sapiens)
p-6Y FLT3 mutant dimers:GRB2:p-Y GAB2:PTPN11 [plasma membrane] (Homo sapiens)
p-6Y FLT3 mutant dimers:GRB2:p-Y GAB2 [plasma membrane] (Homo sapiens)
p-6Y FLT3 mutant dimers:GRB2 [plasma membrane] (Homo sapiens)
p-6Y FLT3 extracellular domain, kinase domain and juxtamembrane domain mutant dimers [plasma membrane] (Homo sapiens)
Participants
members
p-6Y FLT3 S451F dimer [plasma membrane]
(Homo sapiens)
p-6Y juxtamembrane domain mutant dimers of FLT3 [plasma membrane]
(Homo sapiens)
p-6Y kinase domain mutant dimers of FLT3 [plasma membrane]
(Homo sapiens)
Participates
as a component of
p-6Y FLT3 mutant dimers:GRB2:SOS1 [plasma membrane] (Homo sapiens)
p-6Y FLT3 mutant dimers:GRB2 [plasma membrane] (Homo sapiens)
as an output of
Constitutive phosphorylation of FLT3 mutants (Homo sapiens)
as an input of
FLT3 mutant dimers bind GRB2 (Homo sapiens)
Disease
Name
Identifier
Synonyms
cancer
DOID:162
malignant tumor, malignant neoplasm, primary cancer
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