Spike translocates to ERGIC

Stable Identifier
R-HSA-9694780
Type
Reaction [uncertain]
Species
Homo sapiens
Related Species
Severe acute respiratory syndrome coronavirus 2
Compartment
endoplasmic reticulum membrane, endoplasmic reticulum-Golgi intermediate compartment
ReviewStatus
5/5
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Spike translocates to ERGIC
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Trimmed SARS-CoV-2 Spike protein is transported by COPII-coated ER-to-Golgi transport vesicles to the ERGIC (ER-Golgi Intermediate Compartment) (Mendonça et al, 2021; Boson et al, 2021). The Spike cytoplasmic tail contains COPII binding sites that direct the export of the newly made Spike out of the ER and into the ERGIC where virus assembly starts (Cattin-Ortolá et al, 2021).
Literature References
PubMed ID Title Journal Year
33229438 The SARS-CoV-2 envelope and membrane proteins modulate maturation and retention of the spike protein, allowing assembly of virus-like particles

Boson, B, Legros, V, Zhou, B, Siret, E, Mathieu, C, Cosset, FL, Lavillette, D, Denolly, S

J Biol Chem 2021
34330917 Correlative multi-scale cryo-imaging unveils SARS-CoV-2 assembly and egress

Mendonça, L, Howe, A, Gilchrist, JB, Sheng, Y, Sun, D, Knight, ML, Zanetti-Domingues, LC, Bateman, B, Krebs, AS, Chen, L, Radecke, J, Li, VD, Ni, T, Kounatidis, I, Koronfel, MA, Szynkiewicz, M, Harkiolaki, M, Martin-Fernandez, ML, James, W, Zhang, P

Nat Commun 2021
34504087 Sequences in the cytoplasmic tail of SARS-CoV-2 Spike facilitate expression at the cell surface and syncytia formation

Cattin-Ortolá, J, Welch, LG, Maslen, SL, Papa, G, James, LC, Munro, S

Nat Commun 2021
Participants
Input
Output
Participates
as an event of
Disease
Name Identifier Synonyms
COVID-19 DOID:0080600 2019 Novel Coronavirus (2019-nCoV), Wuhan seafood market pneumonia virus infection, 2019-nCoV infection, Wuhan coronavirus infection
Cross References
Mondo
Authored
Stephan, R  (2020-07-22)
Reviewed
Acencio, ML  (2020-09-09)
Created
Cook, J  (2020-07-07)
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