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Uncoating of SARS-CoV-2 Genome
Stable Identifier
R-HSA-9694723
Type
Reaction [dissociation]
Species
Homo sapiens
Related Species
Severe acute respiratory syndrome coronavirus 2
Compartment
cytosol
ReviewStatus
5/5
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Disease (Homo sapiens)
Infectious disease (Homo sapiens)
Viral Infection Pathways (Homo sapiens)
SARS-CoV Infections (Homo sapiens)
SARS-CoV-2 Infection (Homo sapiens)
Early SARS-CoV-2 Infection Events (Homo sapiens)
Attachment and Entry (Homo sapiens)
Uncoating of SARS-CoV-2 Genome (Homo sapiens)
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This COVID-19 event has been created by a combination of computational inference (see https://reactome.org/documentation/inferred-events) from SARS-CoV-1 data and manual curation, as described in the summation for the overall SARS-CoV-2 infection pathway.
The viral nucleocapsid complex, released into the host cell cytosol, dissociates to release the viral RNA genome (Fung & Liu 2019).
Literature References
PubMed ID
Title
Journal
Year
31226023
Human Coronavirus: Host-Pathogen Interaction
Fung, TS
,
Liu, DX
Annu. Rev. Microbiol.
2019
Participants
Input
encapsidated SARS-CoV-2 genomic RNA (plus strand) [cytosol]
(Severe acute respiratory syndrome coronavirus 2)
Output
m7G(5')pppAm-capped, polyadenylated SARS-CoV-2 genomic RNA (plus strand) [cytosol]
(Severe acute respiratory syndrome coronavirus 2)
x 150
N dimer [cytosol]
(Severe acute respiratory syndrome coronavirus 2)
Participates
as an event of
Attachment and Entry (Homo sapiens)
Inferred From
Uncoating of SARS-CoV-1 Genome (Homo sapiens)
Disease
Name
Identifier
Synonyms
COVID-19
DOID:0080600
2019 Novel Coronavirus (2019-nCoV), Wuhan seafood market pneumonia virus infection, 2019-nCoV infection, Wuhan coronavirus infection
Authored
Gillespie, ME (2020-09-09)
Reviewed
Acencio, ML (2020-09-09)
Created
Cook, J (2020-07-07)
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