O-glycosylation of 3a is terminated

Stable Identifier
R-HSA-9694718
Type
Reaction [transition]
Species
Homo sapiens
Related Species
Severe acute respiratory syndrome coronavirus 2
Compartment
endoplasmic reticulum-Golgi intermediate compartment
ReviewStatus
5/5
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O-glycosylation of 3a is terminated
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This COVID-19 event has been created by a combination of computational inference (see https://reactome.org/documentation/inferred-events) from SARS-CoV-1 data and manual curation, as described in the summation for the overall SARS-CoV-2 infection pathway.

A sialyltransferase adds a terminal sialic acid moiety to protein 3a with an O-linked glycosyl side chain. This glycosylated form later is associated with the virion (Oostra et al, 2006)
Literature References
PubMed ID Title Journal Year
16474139 Glycosylation of the severe acute respiratory syndrome coronavirus triple-spanning membrane proteins 3a and M

de Haan, CA, de Groot, RJ, Oostra, M, Rottier, PJ

J. Virol. 2006
Participants
Input
Output
Participates
as an event of
Catalyst Activity

sialyltransferase activity of sialyltransferases

Physical Entity
sialyltransferases [Golgi membrane] (Homo sapiens)
Activity
sialyltransferase activity (GO:0008373)
Inferred From
O-glycosylation of 3a is terminated (Homo sapiens)
Disease
Name Identifier Synonyms
COVID-19 DOID:0080600 2019 Novel Coronavirus (2019-nCoV), Wuhan seafood market pneumonia virus infection, 2019-nCoV infection, Wuhan coronavirus infection
Authored
Stephan, R  (2020-08-28)
Reviewed
Acencio, ML  (2020-09-09)
Created
Cook, J  (2020-07-07)
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