Spike trimer glycoside chains are extended

Stable Identifier
R-HSA-9694656
Type
Reaction [uncertain]
Species
Homo sapiens
Related Species
Severe acute respiratory syndrome coronavirus 2
Compartment
endoplasmic reticulum-Golgi intermediate compartment
ReviewStatus
5/5
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Spike trimer glycoside chains are extended
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Of the 22 glycosylated asparagine residues on the Spike protein 14 are further processed to get complex N-glycan sidechains (Watanabe et al, 2020).
Literature References
PubMed ID Title Journal Year
32366695 Site-specific glycan analysis of the SARS-CoV-2 spike

Watanabe, Y, Allen, JD, Wrapp, D, McLellan, JS, Crispin, M

Science 2020
Participants
Input
Output
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as an event of
Catalyst Activity

alpha-1,6-mannosylglycoprotein 2-beta-N-acetylglucosaminyltransferase activity of MGAT2 [Golgi membrane]

Physical Entity
MGAT2 [Golgi membrane] (Homo sapiens)
Activity
alpha-1,6-mannosylglycoprotein 2-beta-N-acetylglucosaminyltransferase activity (GO:0008455)

acetylglucosaminyltransferase activity of MGAT1 [endoplasmic reticulum-Golgi intermediate compartment membrane]

Physical Entity
MGAT1 [endoplasmic reticulum-Golgi intermediate compartment membrane] (Homo sapiens)
Activity
acetylglucosaminyltransferase activity (GO:0008375)

alpha-mannosidase activity of MAN2A1 [Golgi membrane]

Physical Entity
MAN2A1 [Golgi membrane] (Homo sapiens)
Activity
alpha-mannosidase activity (GO:0004559)
Disease
Name Identifier Synonyms
COVID-19 DOID:0080600 2019 Novel Coronavirus (2019-nCoV), Wuhan seafood market pneumonia virus infection, 2019-nCoV infection, Wuhan coronavirus infection
Cross References
Mondo
Authored
Stephan, R  (2020-07-22)
Reviewed
Acencio, ML  (2020-09-09)
Created
Cook, J  (2020-07-07)
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