Translation of Structural Proteins

Stable Identifier
R-HSA-9694635
Type
Pathway
Species
Homo sapiens
Related Species
Severe acute respiratory syndrome coronavirus 2
Compartment
ReviewStatus
5/5
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This COVID-19 pathway has been created by a combination of computational inference from SARS-CoV-1 data (https://reactome.org/documentation/inferred-events) and manual curation, as described in the summation for the overall SARS-CoV-2 infection pathway.

Virus mRNA is translated according to the ribosomal scanning model. It is capped and polyadenylated, with regions of nontranslated sequences on both the 5' and 3' ends. Structural proteins are encoded after the polymerase/replicase genes by mRNAs 2 (Spike protein), 3, 4 (Envelope protein), 5 (Membrane protein), and 9. mRNA 3 and 9 are bicistronic, the proteins 3a and 9a (Nucleocapsid protein) having functions in virus assembly and structure. Translation happens in the ER with the exception of 9a which is translated by cytosolic free ribosomes (Fung and Liu, 2019).
Literature References
PubMed ID Title Journal Year
31226023 Human Coronavirus: Host-Pathogen Interaction

Fung, TS, Liu, DX

Annu. Rev. Microbiol. 2019
Participants
Participates
Event Information
Go Biological Process
Inferred From
Disease
Name Identifier Synonyms
COVID-19 DOID:0080600 2019 Novel Coronavirus (2019-nCoV), Wuhan seafood market pneumonia virus infection, 2019-nCoV infection, Wuhan coronavirus infection
Authored
Reviewed
Created
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