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Translation of Structural Proteins
Stable Identifier
R-HSA-9694635
Type
Pathway
Species
Homo sapiens
Related Species
Severe acute respiratory syndrome coronavirus 2
Compartment
endoplasmic reticulum lumen
,
cytosol
ReviewStatus
5/5
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SARS-CoV Infections (Homo sapiens)
SARS-CoV-2 Infection (Homo sapiens)
Late SARS-CoV-2 Infection Events (Homo sapiens)
Translation of Structural Proteins (Homo sapiens)
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This COVID-19 pathway has been created by a combination of computational inference from SARS-CoV-1 data (https://reactome.org/documentation/inferred-events) and manual curation, as described in the summation for the overall SARS-CoV-2 infection pathway.
Virus mRNA is translated according to the ribosomal scanning model. It is capped and polyadenylated, with regions of nontranslated sequences on both the 5' and 3' ends. Structural proteins are encoded after the polymerase/replicase genes by mRNAs 2 (Spike protein), 3, 4 (Envelope protein), 5 (Membrane protein), and 9. mRNA 3 and 9 are bicistronic, the proteins 3a and 9a (Nucleocapsid protein) having functions in virus assembly and structure. Translation happens in the ER with the exception of 9a which is translated by cytosolic free ribosomes (Fung and Liu, 2019).
Literature References
PubMed ID
Title
Journal
Year
31226023
Human Coronavirus: Host-Pathogen Interaction
Fung, TS
,
Liu, DX
Annu. Rev. Microbiol.
2019
Participants
Events
mRNA2 is translated to Spike
(Homo sapiens)
mRNA3 is translated to protein 3a
(Homo sapiens)
mRNA4 is translated to protein E
(Homo sapiens)
mRNA5 is translated to protein M
(Homo sapiens)
mRNA9a is translated to Nucleoprotein
(Homo sapiens)
Maturation of nucleoprotein
(Homo sapiens)
Maturation of spike protein
(Homo sapiens)
Maturation of protein 3a
(Homo sapiens)
Maturation of protein E
(Homo sapiens)
Maturation of protein M
(Homo sapiens)
Participates
as an event of
Late SARS-CoV-2 Infection Events (Homo sapiens)
Event Information
Go Biological Process
viral translation (0019081)
Inferred From
Translation of Structural Proteins (Homo sapiens)
Disease
Name
Identifier
Synonyms
COVID-19
DOID:0080600
2019 Novel Coronavirus (2019-nCoV), Wuhan seafood market pneumonia virus infection, 2019-nCoV infection, Wuhan coronavirus infection
Authored
Stephan, R (2020-07-22)
Reviewed
Acencio, ML (2020-09-09)
Created
Cook, J (2020-07-07)
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