Maturation of nucleoprotein

Stable Identifier
R-HSA-9694631
DOI
10.3180/R-HSA-9694631.2
Type
Pathway
Species
Homo sapiens
Related Species
Severe acute respiratory syndrome coronavirus 2
ReviewStatus
5/5
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Maturation of nucleoprotein
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This COVID-19 pathway has been created by a combination of computational inference from SARS-CoV-1 data (https://reactome.org/documentation/inferred-events) and manual curation, as described in the summation for the overall SARS-CoV-2 infection pathway.

Nucleoprotein, the most abundant viral protein expressed during infection, is found in the host cell cytosol, the nucleus and plasma membrane. After phosphorylation and sumoylation it di-/tetramerizes and is moved to the Golgi, the virion budding site (Li et al, 2005; Surjit et al, 2005).
Literature References
PubMed ID Title Journal Year
15848177 Sumoylation of the nucleocapsid protein of severe acute respiratory syndrome coronavirus

Liu, DX, Xiao, H, Li, FQ, Tam, JP

FEBS Lett. 2005
16103198 The severe acute respiratory syndrome coronavirus nucleocapsid protein is phosphorylated and localizes in the cytoplasm by 14-3-3-mediated translocation

Mishra, RN, Kumar, R, Reddy, MK, Chow, VT, Surjit, M, Lal, SK

J. Virol. 2005
Participants
Events
Participates
as an event of
Event Information
Go Biological Process
viral protein processing (0019082)
Inferred From
Maturation of nucleoprotein (Homo sapiens)
Disease
Name Identifier Synonyms
COVID-19 DOID:0080600 2019 Novel Coronavirus (2019-nCoV), Wuhan seafood market pneumonia virus infection, 2019-nCoV infection, Wuhan coronavirus infection
Authored
Stephan, R  (2020-08-28)
Reviewed
Acencio, ML  (2020-09-09)
Created
Cook, J  (2020-07-07)
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