nsp3 cleaves nsp1-4

Stable Identifier
R-HSA-9694625
Type
Reaction [transition]
Species
Homo sapiens
Related Species
Severe acute respiratory syndrome coronavirus 2
Compartment
cytosol, endoplasmic reticulum membrane
ReviewStatus
5/5
Locations in the PathwayBrowser
Expand all
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
nsp3 cleaves nsp1-4
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout
Glycosylated nsp3 (papain-like protease) of SARS-CoV-2 cleaves the N-proximal polyprotein regions at three sites. Polyprotein cleavage is essential for generation of the nsp1-4 viral proteins, and therefore essential for virus replication (Swaim et al, 2020).
Literature References
PubMed ID Title Journal Year
32637945 6-Thioguanine blocks SARS-CoV-2 replication by inhibition of PLpro protease activities

Swaim, CD, Zhao, X, Lenschow, DJ, Boon, ACM, Canadeo, LA, Darling, TL, Perng, YC, Huibregtse, JM, Harastani, HH

bioRxiv 2020
Participants
Input
Output
Participates
as an event of
Catalyst Activity

cysteine-type endopeptidase activity of N-glycan nsp3 [endoplasmic reticulum membrane]

Physical Entity
N-glycan nsp3 [endoplasmic reticulum membrane] (Severe acute respiratory syndrome coronavirus 2)
Activity
cysteine-type endopeptidase activity (GO:0004197)
Disease
Name Identifier Synonyms
COVID-19 DOID:0080600 2019 Novel Coronavirus (2019-nCoV), Wuhan seafood market pneumonia virus infection, 2019-nCoV infection, Wuhan coronavirus infection
Authored
Stephan, R  (2020-08-28)
Reviewed
Acencio, ML  (2020-09-09)
Created
Cook, J  (2020-07-07)
Cite Us!