nsp3 cleaves nsp1-4

Stable Identifier
R-HSA-9694625
Type
Reaction [transition]
Species
Homo sapiens
Related Species
Severe acute respiratory syndrome coronavirus 2
Compartment
cytosol, endoplasmic reticulum membrane
ReviewStatus
5/5
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nsp3 cleaves nsp1-4
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Glycosylated nsp3 (papain-like protease) of SARS-CoV-2 cleaves the N-proximal polyprotein regions at three sites. Polyprotein cleavage is essential for generation of the nsp1-4 viral proteins, and therefore essential for virus replication (Swaim et al, 2020).
Literature References
PubMed ID Title Journal Year
32637945 6-Thioguanine blocks SARS-CoV-2 replication by inhibition of PLpro protease activities

Swaim, CD, Perng, YC, Zhao, X, Canadeo, LA, Harastani, HH, Darling, TL, Boon, ACM, Lenschow, DJ, Huibregtse, JM

bioRxiv 2020
Participants
Input
Output
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as an event of
Catalyst Activity

cysteine-type endopeptidase activity of N-glycan nsp3 [endoplasmic reticulum membrane]

Physical Entity
N-glycan nsp3 [endoplasmic reticulum membrane] (Severe acute respiratory syndrome coronavirus 2)
Activity
cysteine-type endopeptidase activity (GO:0004197)
Disease
Name Identifier Synonyms
COVID-19 DOID:0080600 2019 Novel Coronavirus (2019-nCoV), Wuhan seafood market pneumonia virus infection, 2019-nCoV infection, Wuhan coronavirus infection
Cross References
Mondo
Authored
Stephan, R  (2020-08-28)
Reviewed
Acencio, ML  (2020-09-09)
Created
Cook, J  (2020-07-07)
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