nsp3-4 cleaves itself

Stable Identifier
R-HSA-9694601
Type
Reaction [transition]
Species
Homo sapiens
Related Species
Severe acute respiratory syndrome coronavirus 2
Compartment
cytosol, endoplasmic reticulum membrane
ReviewStatus
5/5
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nsp3-4 cleaves itself
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This COVID-19 event has been created by a combination of computational inference (see https://reactome.org/documentation/inferred-events) from SARS-CoV-1 data and manual curation, as described in the summation for the overall SARS-CoV-2 infection pathway.

To process the nsp3/4 cleavage site, PL-PRO and, presumably, nsp3-4 need to be glycosylated and localized to a membrane (Harcourt et al, 2004).
Literature References
PubMed ID Title Journal Year
15564471 Identification of severe acute respiratory syndrome coronavirus replicase products and characterization of papain-like protease activity

Severson, KM, Baker, SC, Jukneliene, D, Rota, PA, Harcourt, BH, Smith, CM, Bechill, J, Kanjanahaluethai, A

J. Virol. 2004
Participants
Input
Output
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as an event of
Catalyst Activity

cysteine-type endopeptidase activity of N-glycan pp1ab-nsp3-4 [endoplasmic reticulum membrane]

Physical Entity
N-glycan pp1ab-nsp3-4 [endoplasmic reticulum membrane] (Severe acute respiratory syndrome coronavirus 2)
Activity
cysteine-type endopeptidase activity (GO:0004197)
Inferred From
nsp3-4 cleaves itself (Homo sapiens)
Disease
Name Identifier Synonyms
COVID-19 DOID:0080600 2019 Novel Coronavirus (2019-nCoV), Wuhan seafood market pneumonia virus infection, 2019-nCoV infection, Wuhan coronavirus infection
Authored
Stephan, R  (2020-08-28)
Reviewed
Acencio, ML  (2020-09-09)
Created
Cook, J  (2020-07-07)
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