3a localizes to the cell membrane

Stable Identifier
R-HSA-9694572
Type
Reaction [omitted]
Species
Homo sapiens
Related Species
Severe acute respiratory syndrome coronavirus 2
Compartment
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This COVID-19 event has been created by a combination of computational inference (see https://reactome.org/documentation/inferred-events) from SARS-CoV-1 data and manual curation, as described in the summation for the overall SARS-CoV-2 infection pathway.

As it contains cargo sorting motifs in its cytoplasmic domain, protein 3a gets localized by the cell's protein transport system to the cell membrane where it functions as an ion channel (Tan et al, 2004). This ion channel function is necessary for the protein's pro-apoptotic function (Chan et al, 2009)

Literature References
PubMed ID Title Journal Year
15194747 A novel severe acute respiratory syndrome coronavirus protein, U274, is transported to the cell surface and undergoes endocytosis

Tan, YJ, Teng, E, Shen, S, Tan, TH, Goh, PY, Fielding, BC, Ooi, EE, Tan, HC, Lim, SG, Hong, W

J. Virol. 2004
19398035 The ion channel activity of the SARS-coronavirus 3a protein is linked to its pro-apoptotic function

Chan, CM, Tsoi, H, Chan, WM, Zhai, S, Wong, CO, Yao, X, Chan, WY, Tsui, SK, Chan, HY

Int. J. Biochem. Cell Biol. 2009
Participants
Participant Of
Inferred From
Disease
Name Identifier Synonyms
COVID-19 0080600 2019 Novel Coronavirus (2019-nCoV), Wuhan seafood market pneumonia virus infection, 2019-nCoV infection, Wuhan coronavirus infection
Authored
Reviewed
Created
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