nsp14 binds nsp10

Stable Identifier
R-HSA-9694542
Type
Reaction [binding]
Species
Homo sapiens
Related Species
Severe acute respiratory syndrome coronavirus 2
Compartment
cytosol
ReviewStatus
5/5
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nsp14 binds nsp10
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The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout
The interaction between nsp10 and nsp14 is conserved in SARS-CoV-2 virus (Li et al. 2020; Xu et al, 2021; Yan et al, 2021; Baddock et al, 2022). In SARS-CoV-1, nsp10 was shown to form a stable complex with nsp14 (Bouvet et al. 2012) and serve as a co-factor for nsp14, stimulating its 3'->5' exonuclease activity (Bouvet et al. 2012, Subissi et al. 2014, Bouvet et al. 2014).
Literature References
PubMed ID Title Journal Year
32838362 Virus-Host Interactome and Proteomic Survey Reveal Potential Virulence Factors Influencing SARS-CoV-2 Pathogenesis

Liang, Q, Liu, C, Zhu, Z, Qu, Y, Zhu, T, Zhang, Y, Xiao, Z, Wu, P, Li, J, Yang, X, Yin, Y, Wang, C, Guo, M, Liu, Z, Tian, X, Wang, X, Peng, C

Med (N Y) 2020
34297909 Compartmentalization-aided interaction screening reveals extensive high-order complexes within the SARS-CoV-2 proteome

Xu, W, Li, P, Liu, H, Pei, G, Ju, X, Wang, J, Ding, Q

Cell Rep 2021
34143953 Coupling of N7-methyltransferase and 3'-5' exoribonuclease with SARS-CoV-2 polymerase reveals mechanisms for capping and proofreading

Lou, Z, Rao, Z, Zhang, Y, Gao, Y, Li, M, Yan, L, Gao, S, Liu, Z, Zhang, R, Ge, J, Huang, YY, Huang, YC, Zheng, L, Guddat, LW, Wang, T, Yang, Y

Cell 2021
35037045 Characterization of the SARS-CoV-2 ExoN (nsp14ExoN-nsp10) complex: implications for its role in viral genome stability and inhibitor identification

Keown, JR, Grimes, JM, Walker, AP, Ratnaweera, M, Swift, LP, Yosaatmadja, Y, McHugh, PJ, Cruz-Migoni, A, Gileadi, O, Baddock, HT, Brolih, S, Fan, H, Schofield, CJ, Bielinski, M, Fodor, E, Morris, GM

Nucleic Acids Res 2022
Participants
Input
Output
Participates
as an event of
Disease
Name Identifier Synonyms
COVID-19 DOID:0080600 2019 Novel Coronavirus (2019-nCoV), Wuhan seafood market pneumonia virus infection, 2019-nCoV infection, Wuhan coronavirus infection
Authored
Orlic-Milacic, M  (2020-08-12)
Senff-Ribeiro, A  (2020-08-12)
Reviewed
Acencio, ML  (2020-09-09)
Created
Cook, J  (2020-07-07)
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