Maturation of protein E

Stable Identifier
R-HSA-9694493
Type
Pathway
Species
Homo sapiens
Related Species
Severe acute respiratory syndrome coronavirus 2
ReviewStatus
5/5
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Maturation of protein E
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This COVID-19 pathway has been created by a combination of computational inference from SARS-CoV-1 data (https://reactome.org/documentation/inferred-events) and manual curation, as described in the summation for the overall SARS-CoV-2 infection pathway.

The envelope protein (E) gets palmitoylated and ubiquitinated after translation. It forms trimers that show porin activity but does not localize to the cell membrane (Tan et al, 2004; Liao et al, 2006; Alvarez et al, 2011)
Literature References
PubMed ID Title Journal Year
15522242 Expression of SARS-coronavirus envelope protein in Escherichia coli cells alters membrane permeability

Liao, Y, Lescar, J, Tam, JP, Liu, DX

Biochem. Biophys. Res. Commun. 2004
16507314 Biochemical and functional characterization of the membrane association and membrane permeabilizing activity of the severe acute respiratory syndrome coronavirus envelope protein

Liao, Y, Yuan, Q, Torres, J, Tam, JP, Liu, DX

Virology 2006
20409569 The envelope protein of severe acute respiratory syndrome coronavirus interacts with the non-structural protein 3 and is ubiquitinated

Alvarez, E, DeDiego, ML, Nieto-Torres, JL, Jiménez-Guardeño, JM, Marcos-Villar, L, Enjuanes, L

Virology 2010
Participants
Events
Participates
as an event of
Inferred From
Maturation of protein E (Homo sapiens)
Disease
Name Identifier Synonyms
COVID-19 DOID:0080600 2019 Novel Coronavirus (2019-nCoV), Wuhan seafood market pneumonia virus infection, 2019-nCoV infection, Wuhan coronavirus infection
Cross References
Mondo
Authored
Stephan, R  (2020-08-28)
Reviewed
Acencio, ML  (2020-09-09)
Created
Cook, J  (2020-07-07)
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