SUMO-p-N protein dimer binds genomic RNA

Stable Identifier
R-HSA-9694455
Type
Reaction [binding]
Species
Homo sapiens
Related Species
Severe acute respiratory syndrome coronavirus 2
Compartment
cytosol, endoplasmic reticulum-Golgi intermediate compartment membrane
ReviewStatus
5/5
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SUMO-p-N protein dimer binds genomic RNA
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SARS-CoV-2 nucleocapsid protein (N) can undergo liquid-liquid phase separation (LLPS) with RNA. The mutual interactions between N dimers, and those between N dimers and viral RNA drive a polymerization process leading to compaction of long genomic RNA molecules which is key for viral packaging (Wang S et al. 2021; Cubuk J et al. 2021; Jack et al, 2021; Zhao et al, 2021). The LLPS is robust and binds the SARS-CoV-2 membrane protein (M) (Lu S et al, 2021). It also interacts with the stress granule protein G3BP1, and the TAK1 and IKK complexes, the key kinases of NF-κB signaling, to enhance NF-κB activation (Lu S et al, 2021; Wu Y et al, 2021).
Literature References
PubMed ID Title Journal Year
34239064 Targeting liquid-liquid phase separation of SARS-CoV-2 nucleocapsid protein promotes innate antiviral immunity by elevating MAVS activity

Zhou, F, Lou, L, Dai, T, Yang, B, Zhang, L, Wang, S, Huang, H, Chu, F, Qin, Z, Lu, H, Pan, T

Nat Cell Biol 2021
33479198 The SARS-CoV-2 nucleocapsid phosphoprotein forms mutually exclusive condensates with RNA and the membrane-associated M protein

Diedrich, JK, Lu, S, Yates, JR, Villa, E, Cao, Y, Ye, Q, Corbett, KD, Cleveland, DW, Singh, D

Nat Commun 2021
33594360 Energetic and structural features of SARS-CoV-2 N-protein co-assemblies with nucleic acids

Patterson, GH, Li, Y, Wu, D, Valkov, E, Adão, RC, Schuck, P, Piszczek, G, Zhao, H, Nguyen, A

bioRxiv 2021
33895773 RNA-induced liquid phase separation of SARS-CoV-2 nucleocapsid protein facilitates NF-κB hyper-activation and inflammation

Xie, W, Ma, L, Zhao, J, Zhao, Z, Cai, S, Zhou, L, Cui, J, Jin, S, Zhang, L, Wu, Y, Zhuang, Z

Signal Transduct Target Ther 2021
34634033 SARS-CoV-2 nucleocapsid protein forms condensates with viral genomic RNA

Stanley, S, Ferro, LS, Yildiz, A, Wehri, E, Costa, K, Nguyenla, X, Jack, A, Nadgir, A, Schaletzky, J, Fox, D, Trnka, MJ

PLoS Biol 2021
33782395 The SARS-CoV-2 nucleocapsid protein is dynamic, disordered, and phase separates with RNA

Alston, JJ, Bowman, GR, Zimmerman, MI, Ward, MD, Stuchell-Brereton, MD, Holehouse, AS, Griffith, D, Hall, KB, Wagoner, JA, Soranno, A, Incicco, JJ, Singh, S, Vithani, N, Cubuk, J

Nat Commun 2021
Participants
Input
Output
Participates
as an event of
Disease
Name Identifier Synonyms
COVID-19 DOID:0080600 2019 Novel Coronavirus (2019-nCoV), Wuhan seafood market pneumonia virus infection, 2019-nCoV infection, Wuhan coronavirus infection
Authored
Rothfels, K  (2020-07-30)
Reviewed
Acencio, ML  (2020-09-09)
Created
Cook, J  (2020-07-07)
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