Unphosphorylated nucleoprotein translocates to the plasma membrane

Stable Identifier
R-HSA-9694373
Type
Reaction [uncertain]
Species
Homo sapiens
Related Species
Severe acute respiratory syndrome coronavirus 2
Compartment
cytosol, plasma membrane
ReviewStatus
5/5
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Unphosphorylated nucleoprotein translocates to the plasma membrane
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This COVID-19 event has been created by a combination of computational inference (see https://reactome.org/documentation/inferred-events) from SARS-CoV-1 data and manual curation, as described in the summation for the overall SARS-CoV-2 infection pathway.

Significant amounts of the unphosphorylated N protein are associated with the cell membrane (Surjit et al, 2005)
Literature References
PubMed ID Title Journal Year
16103198 The severe acute respiratory syndrome coronavirus nucleocapsid protein is phosphorylated and localizes in the cytoplasm by 14-3-3-mediated translocation

Mishra, RN, Kumar, R, Reddy, MK, Chow, VT, Surjit, M, Lal, SK

J. Virol. 2005
Participants
Input
Output
Participates
as an event of
Inferred From
Unphosphorylated nucleoprotein translocates to the plasma membrane (Homo sapiens)
Disease
Name Identifier Synonyms
COVID-19 DOID:0080600 2019 Novel Coronavirus (2019-nCoV), Wuhan seafood market pneumonia virus infection, 2019-nCoV infection, Wuhan coronavirus infection
Authored
Stephan, R  (2020-08-28)
Reviewed
Acencio, ML  (2020-09-09)
Created
Cook, J  (2020-07-07)
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