Dimerisation of nucleoprotein

Stable Identifier
R-HSA-9694363
Type
Reaction [binding]
Species
Homo sapiens
Related Species
Severe acute respiratory syndrome coronavirus 2
Compartment
cytosol
ReviewStatus
5/5
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Dimerisation of nucleoprotein
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Nucleoprotein of SARS-Cov-2 forms stable dimers in solution that partly oligomerize further. The predominant form interacting with RNA is the dimer, with tetramer and higher oligomers appearing temporarily (Wu et al, 2021; Zhao et al, 2021; Slavin et al, 2021; Ye et al, 2020).
Literature References
PubMed ID Title Journal Year
32637943 Phosphorylation modulates liquid-liquid phase separation of the SARS-CoV-2 N protein

Carlson, CR, Asfaha, JB, Ghent, CM, Howard, CJ, Hartooni, N, Morgan, DO

bioRxiv 2020
33794152 Multivalent binding of the partially disordered SARS-CoV-2 nucleocapsid phosphoprotein dimer to RNA

Forsythe, HM, Rodriguez Galvan, J, Yu, Z, Pinckney, S, Reardon, P, Cooley, RB, Zhu, P, Rolland, AD, Prell, JS, Barbar, E

Biophys J 2021
32654247 Architecture and self-assembly of the SARS-CoV-2 nucleocapsid protein

Ye, Q, West, AMV, Silletti, S, Corbett, KD

Protein Sci. 2020
34095780 Characterization of SARS-CoV-2 nucleocapsid protein reveals multiple functional consequences of the C-terminal domain

Wu, C, Qavi, AJ, Hachim, A, Kavian, N, Cole, AR, Moyle, AB, Wagner, ND, Sweeney-Gibbons, J, Rohrs, HW, Gross, ML, Peiris, JSM, Basler, CF, Farnsworth, CW, Valkenburg, SA, Amarasinghe, GK, Leung, DW

iScience 2021
34373319 Targeted in situ cross-linking mass spectrometry and integrative modeling reveal the architectures of three proteins from SARS-CoV-2

Slavin, M, Zamel, J, Zohar, K, Eliyahu, T, Braitbard, M, Brielle, E, Baraz, L, Stolovich-Rain, M, Friedman, A, Wolf, DG, Rouvinski, A, Linial, M, Schneidman-Duhovny, D, Kalisman, N

Proc Natl Acad Sci U S A 2021
33594360 Energetic and structural features of SARS-CoV-2 N-protein co-assemblies with nucleic acids

Zhao, H, Wu, D, Nguyen, A, Li, Y, Adão, RC, Valkov, E, Patterson, GH, Piszczek, G, Schuck, P

bioRxiv 2021
Participants
Input
Output
Participates
as an event of
Disease
Name Identifier Synonyms
COVID-19 DOID:0080600 2019 Novel Coronavirus (2019-nCoV), Wuhan seafood market pneumonia virus infection, 2019-nCoV infection, Wuhan coronavirus infection
Cross References
Mondo
Authored
Stephan, R  (2020-08-28)
Reviewed
Acencio, ML  (2020-09-09)
Created
Cook, J  (2020-07-07)
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