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Nucleoprotein translocates to the nucleolus
Stable Identifier
R-HSA-9694345
Type
Reaction [uncertain]
Species
Homo sapiens
Related Species
Severe acute respiratory syndrome coronavirus 2
Compartment
cytosol
,
nucleolus
ReviewStatus
5/5
Locations in the PathwayBrowser
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Disease (Homo sapiens)
Infectious disease (Homo sapiens)
Viral Infection Pathways (Homo sapiens)
SARS-CoV Infections (Homo sapiens)
SARS-CoV-2 Infection (Homo sapiens)
Late SARS-CoV-2 Infection Events (Homo sapiens)
Translation of Structural Proteins (Homo sapiens)
Maturation of nucleoprotein (Homo sapiens)
Nucleoprotein translocates to the nucleolus (Homo sapiens)
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This COVID-19 event has been created by a combination of computational inference (see https://reactome.org/documentation/inferred-events) from SARS-CoV-1 data and manual curation, as described in the summation for the overall SARS-CoV-2 infection pathway.
A certain part of the nucleoprotein can be found in the nucleolus. This localisation seems to depend on the protein's sumoylation (Li et al, 2005)
Literature References
PubMed ID
Title
Journal
Year
15848177
Sumoylation of the nucleocapsid protein of severe acute respiratory syndrome coronavirus
Liu, DX
,
Xiao, H
,
Li, FQ
,
Tam, JP
FEBS Lett.
2005
Participants
Input
N dimer [cytosol]
(Severe acute respiratory syndrome coronavirus 2)
Output
N dimer [nucleolus]
(Severe acute respiratory syndrome coronavirus 2)
Participates
as an event of
Maturation of nucleoprotein (Homo sapiens)
Inferred From
Nucleoprotein translocates to the nucleolus (Homo sapiens)
Disease
Name
Identifier
Synonyms
COVID-19
DOID:0080600
2019 Novel Coronavirus (2019-nCoV), Wuhan seafood market pneumonia virus infection, 2019-nCoV infection, Wuhan coronavirus infection
Authored
Stephan, R (2020-08-28)
Reviewed
Acencio, ML (2020-09-09)
Created
Cook, J (2020-07-07)
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