Trimmed spike protein binds to calnexin

Stable Identifier
R-HSA-9694337
Type
Reaction [transition]
Species
Homo sapiens
Related Species
Severe acute respiratory syndrome coronavirus 2
Compartment
endoplasmic reticulum lumen
ReviewStatus
5/5
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Trimmed spike protein binds to calnexin
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This COVID-19 event has been created by a combination of computational inference (see https://reactome.org/documentation/inferred-events) from SARS-CoV-1 data and manual curation, as described in the summation for the overall SARS-CoV-2 infection pathway.

Calnexin transiently binds the unfolded spike protein and prevents its aggregation and premature degradation, ensuring its correct folding (Fukushi et al, 2012).
Literature References
PubMed ID Title Journal Year
22915798 Monitoring of S protein maturation in the endoplasmic reticulum by calnexin is important for the infectivity of severe acute respiratory syndrome coronavirus

Fukushi, M, Yoshinaka, Y, Matsuoka, Y, Hatakeyama, S, Ishizaka, Y, Kirikae, T, Sasazuki, T, Miyoshi-Akiyama, T

J. Virol. 2012
Participants
Input
Output
Participates
as an event of
Catalyst Activity

unfolded protein binding activity of CANX [endoplasmic reticulum lumen]

Physical Entity
CANX [endoplasmic reticulum lumen] (Homo sapiens)
Activity
unfolded protein binding (GO:0051082)
Inferred From
Trimmed spike protein binds to calnexin (Homo sapiens)
Disease
Name Identifier Synonyms
COVID-19 DOID:0080600 2019 Novel Coronavirus (2019-nCoV), Wuhan seafood market pneumonia virus infection, 2019-nCoV infection, Wuhan coronavirus infection
Cross References
Mondo
Authored
Stephan, R  (2020-07-22)
Reviewed
Acencio, ML  (2020-09-09)
Created
Cook, J  (2020-07-07)
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