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mRNA1 is translated to pp1a
Stable Identifier
R-HSA-9694334
Type
Reaction [uncertain]
Species
Homo sapiens
Related Species
Severe acute respiratory syndrome coronavirus 2
Compartment
cytosol
ReviewStatus
5/5
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SARS-CoV Infections (Homo sapiens)
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Early SARS-CoV-2 Infection Events (Homo sapiens)
Translation of Replicase and Assembly of the Replication Transcription Complex (Homo sapiens)
mRNA1 is translated to pp1a (Homo sapiens)
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This COVID-19 event has been created by a combination of computational inference (see https://reactome.org/documentation/inferred-events) from SARS-CoV-1 data and manual curation, as described in the summation for the overall SARS-CoV-2 infection pathway.
In most translation attempts the genomic viral mRNA1 in the cytosol is translated to a shortened polyprotein, pp1a, that does not contain genome replication enzymes (Baranov et al, 2005).
Literature References
PubMed ID
Title
Journal
Year
15680415
Programmed ribosomal frameshifting in decoding the SARS-CoV genome
Baranov, PV
,
Atkins, JF
,
Henderson, CM
,
Howard, MT
,
Gesteland, RF
,
Anderson, CB
Virology
2005
Participants
Input
m7G(5')pppAm-capped, polyadenylated SARS-CoV-2 genomic RNA (plus strand) [cytosol]
(Severe acute respiratory syndrome coronavirus 2)
Output
pp1a [cytosol]
(Severe acute respiratory syndrome coronavirus 2)
Participates
as an event of
Translation of Replicase and Assembly of the Replication Transcription Complex (Homo sapiens)
Inferred From
mRNA1 is translated to pp1a (Homo sapiens)
Disease
Name
Identifier
Synonyms
COVID-19
DOID:0080600
2019 Novel Coronavirus (2019-nCoV), Wuhan seafood market pneumonia virus infection, 2019-nCoV infection, Wuhan coronavirus infection
Authored
Stephan, R (2020-08-28)
Reviewed
Acencio, ML (2020-09-09)
Created
Cook, J (2020-07-07)
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