mRNA1 is translated to pp1a

Stable Identifier
R-HSA-9694334
Type
Reaction [uncertain]
Species
Homo sapiens
Related Species
Severe acute respiratory syndrome coronavirus 2
Compartment
ReviewStatus
5/5
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This COVID-19 event has been created by a combination of computational inference (see https://reactome.org/documentation/inferred-events) from SARS-CoV-1 data and manual curation, as described in the summation for the overall SARS-CoV-2 infection pathway.

In most translation attempts the genomic viral mRNA1 in the cytosol is translated to a shortened polyprotein, pp1a, that does not contain genome replication enzymes (Baranov et al, 2005).
Literature References
PubMed ID Title Journal Year
15680415 Programmed ribosomal frameshifting in decoding the SARS-CoV genome

Baranov, PV, Atkins, JF, Henderson, CM, Howard, MT, Gesteland, RF, Anderson, CB

Virology 2005
Participants
Participates
Inferred From
Disease
Name Identifier Synonyms
COVID-19 DOID:0080600 2019 Novel Coronavirus (2019-nCoV), Wuhan seafood market pneumonia virus infection, 2019-nCoV infection, Wuhan coronavirus infection
Authored
Reviewed
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