This COVID-19 event has been created by a combination of computational inference (see https://reactome.org/documentation/inferred-events) from SARS-CoV-1 data and manual curation, as described in the summation for the overall SARS-CoV-2 infection pathway.To process the nsp3/4 cleavage site, PL-PRO and, presumably, nsp3-4 need to be glycosylated and localized to a membrane (Harcourt et al, 2004)
Severson, KM, Baker, SC, Jukneliene, D, Rota, PA, Harcourt, BH, Smith, CM, Bechill, J, Kanjanahaluethai, A
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