E pentamer is transported to the Golgi

Stable Identifier
R-HSA-9694294
Type
Reaction [uncertain]
Species
Homo sapiens
Related Species
Severe acute respiratory syndrome coronavirus 2
Compartment
endoplasmic reticulum membrane, Golgi membrane
ReviewStatus
5/5
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E pentamer is transported to the Golgi
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The small envelope protein (E) of the coronavirus SARS‐CoV‐2 localizes to the ER and the ERGIC in HEK 293S cells (Cabrera-Garcia et al, 2021). At 18 to 24 h after initial delivery in HeLa and SW1573 human alveolar cells, amphipol E constructs were seen to partially overlap with the trans-Golgi marker Golgin 97 in the area surrounding the Golgi but not within the cis-Golgi, ultimately residing in the trans-Golgi network (TGN) and associated vesicles. The localization of delivered E to swollen TGN vesicles is likely disease relevant given that progeny virions are known to accumulate in the TGN before cellular egress (Hutchison et al, 2021).
Literature References
PubMed ID Title Journal Year
33709461 The envelope protein of SARS-CoV-2 increases intra-Golgi pH and forms a cation channel that is regulated by pH

Yazawa, M, Bekdash, R, Abbott, GW, Cabrera-Garcia, D, Harrison, NL

J Physiol 2021
34237302 Recombinant SARS-CoV-2 envelope protein traffics to the trans-Golgi network following amphipol-mediated delivery into human cells

Hadziselimovic, A, Van Horn, WD, Capone, R, Luu, DD, Sanders, CR, Hutchison, JM, Shah, KH

J Biol Chem 2021
21450821 Identification of a Golgi complex-targeting signal in the cytoplasmic tail of the severe acute respiratory syndrome coronavirus envelope protein

Lin, LD, Cohen, JR, Machamer, CE

J. Virol. 2011
21524776 Subcellular location and topology of severe acute respiratory syndrome coronavirus envelope protein

Regla-Nava, JA, Jiménez-Guardeño, JM, DeDiego, ML, Enjuanes, L, Llorente, M, Shuo, S, Kremer, L, Alvarez, E, Nieto-Torres, JL

Virology 2011
Participants
Input
Output
Participates
as an event of
Disease
Name Identifier Synonyms
COVID-19 DOID:0080600 2019 Novel Coronavirus (2019-nCoV), Wuhan seafood market pneumonia virus infection, 2019-nCoV infection, Wuhan coronavirus infection
Authored
Stephan, R  (2020-08-28)
Reviewed
Acencio, ML  (2020-09-09)
Created
Cook, J  (2020-07-07)
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