Cleavage of S protein into S1:S2

Stable Identifier
R-HSA-9694287
Type
Reaction [transition]
Species
Homo sapiens
Related Species
Severe acute respiratory syndrome coronavirus 2
Compartment
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This COVID-19 event has been created by a combination of computational inference (see https://reactome.org/documentation/inferred-events) from SARS-CoV-1 data and manual curation, as described in the summation for the overall SARS-CoV-2 infection pathway.

Within the host cell endocytic vesicle, SARS-CoV-2 Spike (S) protein is cleaved between residues 797 and 798 by cathepsin L1 (CTSL) (Huang et al. 2006). The roles of S protein in viral binding to the host cell membrane and fusion of viral and host cell membranes and thus the central role of S protein in determining the host range and tissue tropisms of the virus are reviewed by Belouzard et al. (2012).

Literature References
PubMed ID Title Journal Year
19321428 Activation of the SARS coronavirus spike protein via sequential proteolytic cleavage at two distinct sites

Belouzard, S, Chu, VC, Whittaker, GR

Proc. Natl. Acad. Sci. U.S.A. 2009
22816037 Mechanisms of coronavirus cell entry mediated by the viral spike protein

Belouzard, S, Millet, JK, Licitra, BN, Whittaker, GR

Viruses 2012
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
serine-type endopeptidase activity of Cathepsin L1 [endocytic vesicle lumen]
Physical Entity
Activity
This event is regulated
Inferred From
Disease
Name Identifier Synonyms
COVID-19 0080600 2019 Novel Coronavirus (2019-nCoV), Wuhan seafood market pneumonia virus infection, 2019-nCoV infection, Wuhan coronavirus infection
Authored
Reviewed
Created
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