Reactome | RAP1GDS1 [mitochondrial outer membrane]

RAP1GDS1 [mitochondrial outer membrane]

Stable Identifier

R-HSA-9693756

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

mitochondrial outer membrane

Synonyms

Vimar

Locations in the PathwayBrowser for interactor UniProt:P60763 RAC3

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External Reference Information

External Reference

UniProt:P52306 RAP1GDS1

Gene Names

RAP1GDS1, SMGGDS

Chain

chain:1-607

Reference Genes

BioGPS Gene:5910 RAP1GDS1

COSMIC (genes):RAP1GDS1 RAP1GDS1

CTD Gene:5910 RAP1GDS1

dbSNP Gene:5910 RAP1GDS1

ENSEMBL:ENSG00000138698 RAP1GDS1

HGNC:9859 RAP1GDS1

KEGG:hsa:5910 RAP1GDS1

Monarch:5910 RAP1GDS1

NCBI Gene:5910 RAP1GDS1

OMIM:179502 RAP1GDS1

UCSC:P52306 RAP1GDS1

Reference Transcript

Cross References

RefSeq

NP_066982.3, NP_001093900.1, NP_001093897.1, NP_001093899.1, NP_001093898.1, NP_001093896.1

OpenTargets

ENSG00000138698

ENSEMBL

ENSP00000407157, ENSG00000138698, ENSP00000386153, ENSP00000264572, ENST00000339360, ENSP00000340454, ENSP00000369503, ENST00000264572, ENST00000453712, ENSP00000386223, ENST00000408927, ENST00000380158, ENST00000408900

GeneCards

RAP1GDS1

HPA

ENSG00000138698-RAP1GDS1

PRO

P52306

Pharos - Targets

P52306

GlyGen

P52306

HMDB Protein

HMDBP01779

PDB

5ZHX, 5XGC

Interactors (36)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P61586 RHOA	6	RHOA [plasma membrane] (R-HSA-194510) RHOA [cell junction] (R-HSA-2134503) RHOA [cytosol] (R-HSA-194866) RHOA [ficolin-1-rich granule membrane] (R-HSA-6804971) RHOA [secretory granule membrane] (R-HSA-6804980) RHOA [endoplasmic reticulum membrane] (R-HSA-5672082)	0.837	8
UniProt:P0DTD1-PRO_0000449620 REP			0.836	6
UniProt:P63000 RAC1	6	RAC1 [plasma membrane] (R-HSA-351141) RAC1 [cytosol] (R-HSA-442615) GGC-PalmC-RAC1 [plasma membrane] (R-HSA-2316446) RAC1 [ficolin-1-rich granule membrane] (R-HSA-6804802) RAC1 [secretory granule membrane] (R-HSA-6804770) RAC1 [endoplasmic reticulum membrane] (R-HSA-5672076)	0.798	5
UniProt:P08134 RHOC	3	RHOC [plasma membrane] (R-HSA-194870) RHOC [cytosol] (R-HSA-194853) RHOC [endoplasmic reticulum membrane] (R-HSA-9714362)	0.725	5
UniProt:Q9UF11 PKHB1			0.666	5
UniProt:P61224 RAP1B	2	RAP1B [plasma membrane] (R-HSA-377590) RAP1B [azurophil granule membrane] (R-HSA-6804972)	0.643	3
UniProt:P59190 RAB15	2	GGC-RAB15 [cytosol] (R-HSA-8873782) RAB15 [cytosol] (R-HSA-8873682)	0.643	4
UniProt:Q9Y3L5 RAP2C	2	RAP2C [plasma membrane] (R-HSA-6804983) RAP2C [tertiary granule membrane] (R-HSA-6804975)	0.643	4
UniProt:Q96HU8 DIRA2			0.643	4
UniProt:O95057 DIRA1			0.643	4
UniProt:Q9Y3Q8 T22D4			0.643	5
UniProt:P01112 HRAS	20	S-Farn-Me-2xPalmS HRAS [plasma membrane] (R-HSA-9647912) proHRAS [cytosol] (R-HSA-9647765) S-Farn-proHRAS [endoplasmic reticulum membrane] (R-HSA-9647918) S-Farn-HRAS [endoplasmic reticulum membrane] (R-HSA-9647788) S-Farn-Me HRAS [endoplasmic reticulum membrane] (R-HSA-9647796) S-Farn-Me PalmS HRAS [Golgi membrane] (R-HSA-9647896) HRAS [plasma membrane] (R-HSA-62717) S-Farn-Me HRAS [plasma membrane] (R-HSA-9665052) HRAS G12C [plasma membrane] (R-HSA-9656561) HRAS G12D [plasma membrane] (R-HSA-9656564) HRAS K117N [plasma membrane] (R-HSA-9656603) HRAS G13S [plasma membrane] (R-HSA-9656574) HRAS G13D [plasma membrane] (R-HSA-9656572) HRAS G13V [plasma membrane] (R-HSA-9656579) HRAS K117R [plasma membrane] (R-HSA-9656010) HRAS G13C [plasma membrane] (R-HSA-9656008) HRAS T58I [plasma membrane] (R-HSA-9656014) HRAS G12S [plasma membrane] (R-HSA-6802343) HRAS G12V [plasma membrane] (R-HSA-6802350) HRAS G13R [plasma membrane] (R-HSA-6802368)	0.589	2
UniProt:Q9NS73-5 MBIP			0.556	3
UniProt:P00533 EGFR	20	p-5Y-EGFRvIII [plasma membrane] (R-HSA-1248649) EGFRvIII [plasma membrane] (R-HSA-1214162) p-6Y-EGFR E746_A750del;T790M [plasma membrane] (R-HSA-1182985) p-6Y-EGFR L858R;T790M [plasma membrane] (R-HSA-1182984) p-6Y-EGFR A767_V769dup [plasma membrane] (R-HSA-1996343) p-6Y-EGFR N771_H773dup [plasma membrane] (R-HSA-1996342) p-6Y-EGFR K739_I744dup [plasma membrane] (R-HSA-1996346) p-6Y-EGFR D770_N771insNPG [plasma membrane] (R-HSA-1996335) p-6Y-EGFR E746_A750del [plasma membrane] (R-HSA-1181214) p-6Y-EGFR L858R [plasma membrane] (R-HSA-1173211) p-6Y-EGFR G719S [plasma membrane] (R-HSA-1169417) p-6Y-EGFR L747_P753delinsS [plasma membrane] (R-HSA-1228038) p-6Y-EGFR L747_A750delinsP [plasma membrane] (R-HSA-1228044) p-6Y-EGFR L747_T751del [plasma membrane] (R-HSA-1228041) p-6Y-EGFR L747_S752del [plasma membrane] (R-HSA-1228040) p-6Y-EGFR L747_T751delinsP [plasma membrane] (R-HSA-1228042) p-6Y-EGFR E746_T751delinsA [plasma membrane] (R-HSA-1228037) p-6Y-EGFR E746_S752delinsV [plasma membrane] (R-HSA-1228039) p-6Y-EGFR L861Q [plasma membrane] (R-HSA-1177541) p-6Y-EGFR A289V [plasma membrane] (R-HSA-1996334)	0.553	2
UniProt:P60953 CDC42	3	CDC42 [plasma membrane] (R-HSA-449545) CDC42 [cytosol] (R-HSA-442630) CDC42 [endoplasmic reticulum membrane] (R-HSA-5672086)	0.547	2
UniProt:P56559 ARL4C	1	ARL4C [plasma membrane] (R-HSA-9618406)	0.527	3
UniProt:P62834 RAP1A	4	RAP1A [plasma membrane] (R-HSA-354118) RAP1A [endosome membrane] (R-HSA-190053) RAP1A [cytosol] (R-HSA-169884) RAP1A [specific granule membrane] (R-HSA-6806137)	0.527	3
UniProt:Q5HYI8 RABL3			0.527	3
UniProt:Q9HBH0 RHOF	2	RHOF [plasma membrane] (R-HSA-194921) RHOF [secretory granule membrane] (R-HSA-6804978)	0.527	3
UniProt:P15153 RAC2	5	RAC2 [endoplasmic reticulum membrane] (R-HSA-9714482) RAC2 [mitochondrial outer membrane] (R-HSA-9714496) RAC2 [phagocytic vesicle membrane] (R-HSA-5668620) RAC2 [cytosol] (R-HSA-195343) RAC2 [plasma membrane] (R-HSA-195339)	0.527	2
UniProt:Q8N5M4 TTC9C			0.527	3
UniProt:Q9NX57 RAB20	2	GGC-RAB20 [cytosol] (R-HSA-8873778) RAB20 [cytosol] (R-HSA-8873710)	0.527	2
UniProt:P10114 RAP2A			0.527	2
UniProt:P62070 RRAS2	1	RRAS2 [plasma membrane] (R-HSA-9715189)	0.527	2
UniProt:Q8TCD5 NT5C	1	NT5C [cytosol] (R-HSA-109467)	0.527	2
UniProt:Q92870 APBB2			0.527	2
UniProt:P17480 UBTF	2	UBTF [nucleoplasm] (R-HSA-73683) p-UBTF [nucleoplasm] (R-HSA-76039)	0.527	3
UniProt:Q6NXR0 IIGP5			0.527	2
UniProt:Q14344 GNA13	1	GNA13 [plasma membrane] (R-HSA-167451)	0.527	3
UniProt:Q13636 RAB31	5	GGC-RAB31 [early endosome membrane] (R-HSA-8877278) GGC-RAB31 [cytosol] (R-HSA-8873974) RAB31 [cytosol] (R-HSA-8873690) RAB31 [plasma membrane] (R-HSA-6804813) RAB31 [secretory granule membrane] (R-HSA-6804797)	0.527	3
UniProt:Q9NRW1 RAB6B	6	RAB6B [endoplasmic reticulum membrane] (R-HSA-8849252) RAB6B [trans-Golgi network membrane] (R-HSA-6810985) RAB6B [Golgi membrane] (R-HSA-8849249) GGC-RAB6B [trans-Golgi network membrane] (R-HSA-8876081) GGC-RAB6B [cytosol] (R-HSA-8874055) RAB6B [cytosol] (R-HSA-6810983)	0.527	3
UniProt:Q9BQS6 HSPB9			0.527	2
UniProt:P10301 RRAS	1	RRAS [plasma membrane] (R-HSA-396959)	0.527	2
UniProt:P60763 RAC3	3	RAC3 [endoplasmic reticulum membrane] (R-HSA-9714693) RAC3 [plasma membrane] (R-HSA-195338) RAC3 [cytosol] (R-HSA-195335)	0.527	2
UniProt:P11234 RALB	1	RALB [cytosol] (R-HSA-171015)	0.527	2
UniProt:Q4LDG9 DNAL1			0.527	3

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