RHOD binds effectors at the mitochondrial outer membrane

Stable Identifier
R-HSA-9693214
Type
Reaction [binding]
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
General
SVG |   | PPTX  | SBGN
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

Active GTP-bound RHOD binds PAK5 and recruits it to the mitochondrial outer membrane (Wu and Frost 2006).

GTP-bound RHOD also binds HINT2 at the mitochondrial outer membrane, which triggers mitochondrial Ca2+ influx (Chen et al. 2017, supported by Bagci et al. 2020).

VRK2, which can localize to the mitochondrial outer membrane was reported to bind active RHOD by Bagci et al. 2020 and is annotated as a candidate effector.

Literature References
PubMed ID Title Journal Year
31871319 Mapping the proximity interaction network of the Rho-family GTPases reveals signalling pathways and regulatory mechanisms

Bagci, H, Sriskandarajah, N, Robert, A, Boulais, J, Elkholi, IE, Tran, V, Lin, ZY, Thibault, MP, Dubé, N, Faubert, D, Hipfner, DR, Gingras, AC, Cote, JF

Nat. Cell Biol. 2020
28947137 HINT2 triggers mitochondrial Ca2+ influx by regulating the mitochondrial Ca2+ uniporter (MCU) complex and enhances gemcitabine apoptotic effect in pancreatic cancer

Chen, L, Sun, Q, Zhou, D, Song, W, Yang, Q, Ju, B, Zhang, L, Xie, H, Zhou, L, Hu, Z, Yao, H, Zheng, S, Wang, W

Cancer Lett 2017
17064668 Multiple Rho proteins regulate the subcellular targeting of PAK5

Wu, X, Frost, JA

Biochem. Biophys. Res. Commun. 2006
Participants
Participates
Orthologous Events
Authored
Reviewed
Created
Cite Us!