Reactome | RHOF binds effectors at the plasma membrane

RHOF binds effectors at the plasma membrane

Stable Identifier

R-HSA-9693125

Type

Reaction [binding]

Species

Homo sapiens

Compartment

plasma membrane, cytosol

ReviewStatus

5/5

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RHOF binds effectors at the plasma membrane

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Active GTP-bound RHOF binds the following effectors:
BAIAP2L1 (Sudhaharan et al. 2016)
BAIAP2L2 (Sudhaharan et al. 2016)
DIAPH1 (Fan et al. 2010)
DIAPH2 (Gorelik et al. 2011)
FARP1 (Fan et al. 2015)

The following candidate RHOF effectors that can localize to cytosol or the plasma membrane were reported by Bagci et al. 2020 to bind active RHOF:
ACTB (Bagci et al. 2020)
ACTN1 (Bagci et al. 2020)
ADD3 (Bagci et al. 2020)
AKAP12 (Bagci et al. 2020)
ARHGAP1 (Bagci et al. 2020)
ARHGAP39 (Bagci et al. 2020)
BASP1 (Bagci et al. 2020)
CAPZB (Bagci et al. 2020)
CAV1 (Bagci et al. 2020)
CPNE8 (Bagci et al. 2020)
DIAPH3 (Bagci et al. 2020)
ESYT1 (Bagci et al. 2020)
FAM169A (Bagci et al. 2020)
LMNB1 (Bagci et al. 2020)
MCAM (Bagci et al. 2020)
MTMR1 (Bagci et al. 2020)
POTEE (Bagci et al. 2020)
RAB7A (Bagci et al. 2020)
SENP1 (Bagci et al. 2020)
SLC4A7 (Bagci et al. 2020)
SNAP23 (Bagci et al. 2020)
SOWAHC (Bagci et al. 2020)
STEAP3 (Bagci et al. 2020)
TMPO (Bagci et al. 2020)
TOR1AIP1 (Bagci et al. 2020)
VAMP3 (Bagci et al. 2020)
VANGL1 (Bagci et al. 2020)

Several putative effectors that localize to endoplasmic reticulum, endosomes or the mitochondrial outer membrane were reported to bind active RHOF by Bagci et al. 2020, but as the localization of RHOF to these cellular compartments has not been established, these effectors have not been annotated:
EMD
LBR
LEMD3
LMAN1
PGRMC2
VRK2

The following putative effectors were reported not to bind active RHOF:
DBN1 (Bagci et al. 2020)
EFHD2 (Bagci et al. 2020)
GOLGA8R (Bagci et al. 2020)
HINT2 (Bagci et al. 2020)
MOSPD2 (Bagci et al. 2020)
STBD1 (Bagci et al. 2020)
VAPB (Bagci et al. 2020)

Literature References

PubMed ID	Title	Journal	Year
25668492	The Rif GTPase regulates cytoskeletal signaling from plexinA4 to promote neurite retraction Fan, L, Yan, H, Pellegrin, S, Morigen, M, Mellor, H	Neurosci. Lett.	2015
27278019	The Rho GTPase Rif signals through IRTKS, Eps8 and WAVE2 to generate dorsal membrane ruffles and filopodia Sudhaharan, T, Sem, KP, Liew, HF, Yu, YH, Goh, WI, Chou, AM, Ahmed, S	J. Cell. Sci.	2016
31871319	Mapping the proximity interaction network of the Rho-family GTPases reveals signalling pathways and regulatory mechanisms Bagci, H, Sriskandarajah, N, Robert, A, Boulais, J, Elkholi, IE, Tran, V, Lin, ZY, Thibault, MP, Dubé, N, Faubert, D, Hipfner, DR, Gingras, AC, Cote, JF	Nat. Cell Biol.	2020
20233848	The small GTPase Rif is an alternative trigger for the formation of actin stress fibers in epithelial cells Fan, L, Pellegrin, S, Scott, A, Mellor, H	J. Cell. Sci.	2010
21119010	Mechanisms of plasma membrane targeting of formin mDia2 through its amino terminal domains Gorelik, R, Yang, C, Kameswaran, V, Dominguez, R, Svitkina, T	Mol. Biol. Cell	2011